Angiotensin receptor (AT2R) agonist C21 prevents cognitive decline after permanent stroke in aged animals—A randomized double- blind pre-clinical study
Sign Up to like & getrecommendations! Published in 2019 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2018.10.010
Abstract: HighlightsC21 reduced weight loss and enhanced recovery in aged rats post‐stroke.C21 preserved non‐spatial and short‐term working memory in aged rats post‐stroke.C21 preserved reference memory and facilitated associative learning post‐stroke.C21 improved cognitive flexibility in aged rats… read more here.
Keywords: post stroke; stroke c21; aged animals; c21 ... See more keywords
Role of interleukin‐10 in the neuroprotective effect of the Angiotensin Type 2 Receptor agonist, compound 21, after ischemia/reperfusion injury
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2017.02.016
Abstract: Introduction We and others have shown that the angiotensin type 2 (AT2) receptor agonist, compound 21 (C21), provides neuroprotection and enhances recovery in rodent stroke models yet the mechanism involved is not known. Moreover, C21… read more here.
Keywords: neuroprotective effect; agonist compound; receptor agonist; c21 ... See more keywords
[OP.7C.05] ANGIOTENSIN AT2 RECEPTOR AGONIST, COMPOUND 21, PREVENTS ABDOMINAL AORTIC ANEURYSM PROGRESSION AND THE DECREASE OF AORTIC WALL DISTENSIBILITY IN THE RAT
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Hypertension"
DOI: 10.1097/01.hjh.0000523164.52997.5d
Abstract: Objective: We studied the effects of selective AT2 receptor agonist, compound 21, (C21) treatment on experimental abdominal aortic aneurysm (AAA) formation in rats. Design and method: AAA was induced by perfusion of isolated aortic segments… read more here.
Keywords: at2 receptor; receptor agonist; distensibility; c21 ... See more keywords
Angiotensin AT2 Receptor Stimulation Alleviates Collagen-Induced Arthritis by Upregulation of Regulatory T Cell Numbers
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.921488
Abstract: The angiotensin AT2 receptor (AT2R) is a main receptor of the protective arm of the renin-angiotensin system and exerts for instance anti-inflammatory effects. The impact of AT2R stimulation on autoimmune diseases such as rheumatoid arthritis… read more here.
Keywords: angiotensin at2; collagen; arthritis; stimulation ... See more keywords
Effects of the Oral Angiotensin II Type 2 Receptor Agonist C21 in Sugen-Hypoxia Induced Pulmonary Hypertension in Rats
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24087478
Abstract: Substantial evidence supports the involvement of the renin-angiotensin system in pulmonary hypertension (PH), and the angiotensin II type 2 receptor (AT2R) is known to exert tissue protective actions. The effect of the selective AT2R agonist… read more here.
Keywords: pulmonary hypertension; angiotensin type; hypoxia; sugen ... See more keywords