Heterodimerization of Munc13 C2A domain with RIM regulates synaptic vesicle docking and priming
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DOI: 10.1038/ncomms15293
Abstract: The presynaptic active zone protein Munc13 is essential for neurotransmitter release, playing key roles in vesicle docking and priming. Mechanistically, it is thought that the C2A domain of Munc13 inhibits the priming function by homodimerization,… read more here.
Keywords: vesicle docking; docking priming; c2a domain; munc13 ... See more keywords
The C2A domain of synaptotagmin is an essential component of the calcium sensor for synaptic transmission
Sign Up to like & getrecommendations! Published in 2020 at "PLoS ONE"
DOI: 10.1371/journal.pone.0228348
Abstract: The synaptic vesicle protein, synaptotagmin, is the principle Ca2+ sensor for synaptic transmission. Ca2+ influx into active nerve terminals is translated into neurotransmitter release by Ca2+ binding to synaptotagmin’s tandem C2 domains, triggering the fast,… read more here.
Keywords: synaptic transmission; c2a domain; hydrophobic residues; c2a ... See more keywords