RIM C2B Domains Target Presynaptic Active Zone Functions to PIP2-Containing Membranes
Sign Up to like & getrecommendations! Published in 2018 at "Neuron"
DOI: 10.1016/j.neuron.2018.03.011
Abstract: Rapid and efficient synaptic vesicle fusion requires a pool of primed vesicles, the nearby tethering of Ca2+ channels, and the presence of the phospholipid PIP2 in the target membrane. Although the presynaptic active zone mediates… read more here.
Keywords: c2b; presynaptic active; rim c2b; active zone ... See more keywords
Enhanced Expansion and Reduced Kiss-and-Run Events in Fusion Pores Steered by Synaptotagmin-1 C2B Domains.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical theory and computation"
DOI: 10.1021/acs.jctc.2c00424
Abstract: The fusion pore controls the release of exocytotic vesicle contents through a precise orchestration of lipids from the fusing membranes and proteins. There is a major lipid reorganization during the different stages in life of… read more here.
Keywords: fusion; synaptotagmin c2b; fusion pore; c2b domains ... See more keywords