Poncirin, an orally active flavonoid exerts antidiabetic complications and improves glucose uptake activating PI3K/Akt signaling pathway in insulin resistant C2C12 cells with anti-glycation capacities.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.104061
Abstract: Poncirin, a natural flavanone glycoside present abundantly in many citrus fruits, contains an extensive range of biological activities. However, the antidiabetic mechanism of poncirin is unexplored yet. In this study, we examined the anti-diabetic prospective… read more here.
Keywords: c2c12 cells; resistant c2c12; poncirin; c2c12 ... See more keywords
Mechanisms of simvastatin myotoxicity: The role of autophagy flux inhibition.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2019.172616
Abstract: Statins are some of the most widely used drugs worldwide, but one of their major side effects is myotoxicity. Using mouse myoblast (C2C12) and human alveolar rhabdomyosarcoma cell lines (RH30) in 2-dimensional (2D) and 3-dimensional… read more here.
Keywords: myotoxicity; simvastatin induced; c2c12; simvastatin myotoxicity ... See more keywords
An herbal formula consisting of Schisandra chinensis (Turcz.) Baill, Lycium chinense Mill and Eucommia ulmoides Oliv alleviates disuse muscle atrophy in rats.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of ethnopharmacology"
DOI: 10.1016/j.jep.2017.10.008
Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Schisandra chinensis (Turcz.) Baill (SC), Lycium chinense Mill (LC) and Eucommia ulmoides Oliv (EU) are representative tonic herbal medicines that help to strengthen body muscles and bones making them stronger according to the… read more here.
Keywords: disuse muscle; formula; muscle; c2c12 ... See more keywords
ActivinA activates Notch1-Shh signaling to regulate proliferation in C2C12 skeletal muscle cells
Sign Up to like & getrecommendations! Published in 2021 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2020.111055
Abstract: The myoblast is a precursor cell that rebuilds muscle tissue after trauma in human and animal skeletal muscle tissue. Proliferation of myoblasts is important for skeletal muscle damage repair and is controlled by numerous transcription… read more here.
Keywords: skeletal muscle; shh signaling; c2c12; proliferation ... See more keywords
Corticosterone biosynthesis in mouse clonal myoblastic C2C12 cells
Sign Up to like & getrecommendations! Published in 2018 at "Steroids"
DOI: 10.1016/j.steroids.2018.07.001
Abstract: Graphical abstract Figure. No Caption available. Highlights3ß‐HSD, cytochrome P450c21 and cytochrome P45011ß, exist in C2C12 cells.C2C12 cells do not reveal P450scc activity, but the cells show sulfatase activity.Cholesterol is not initial substrate for local corticosterone… read more here.
Keywords: c2c12 cells; c2c12; pregnenolone sulfate; clonal myoblastic ... See more keywords
NMR-based metabolomic analysis for the effects of creatine supplementation on mouse myoblast cell line C2C12
Sign Up to like & getrecommendations! Published in 2017 at "Acta Biochimica et Biophysica Sinica"
DOI: 10.1093/abbs/gmx043
Abstract: Creatine (Cr) supplementation has drawn much attention from researchers owing to its widespread efficacy in sports, and more recently, in therapeutic fields. However, the underlying molecular mechanisms remain elusive. Here, we performed nuclear magnetic resonance-based… read more here.
Keywords: supplementation; creatine supplementation; analysis; c2c12 ... See more keywords
Genome-wide survey reveals dynamic effects of folate supplement on DNA methylation and gene expression during C2C12 differentiation.
Sign Up to like & getrecommendations! Published in 2018 at "Physiological genomics"
DOI: 10.1152/physiolgenomics.00094.2017
Abstract: Folic acid supplements taken during pregnancy can prevent neural tube defects and other developmental abnormalities. Here, we explored the effects of folate supplementation on gene expression and DNA methylation during C2C12 differentiation. Based on the… read more here.
Keywords: methylation; c2c12; expression; differentiation ... See more keywords
Bis-Indole–Derived NR4A1 Ligands and Metformin Exhibit NR4A1-Dependent Glucose Metabolism and Uptake in C2C12 Cells
Sign Up to like & getrecommendations! Published in 2018 at "Endocrinology"
DOI: 10.1210/en.2017-03049
Abstract: Treatment of C2C12 muscle cells with metformin or the NR4A1 ligand 1,1-bis(3'-indolyl)-1-(p-hydroxyphenyl)methane (DIM-C-pPhOH) induced NR4A1 and Glut4 messenger RNA and protein expression. Similar results were observed with buttressed (3- or 3,5-substituted) analogs of DIM-C-pPhOH, including… read more here.
Keywords: c2c12 cells; nr4a1 ligands; uptake c2c12; bis indole ... See more keywords
N-acetyl cysteine prevents arecoline-inhibited C2C12 myoblast differentiation through ERK1/2 phosphorylation
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0272231
Abstract: Arecoline is known to induce reactive oxygen species (ROS). Our previous studies showed that arecoline inhibited myogenic differentiation and acetylcholine receptor cluster formation of C2C12 myoblasts. N-acetyl-cysteine (NAC) is a known ROS scavenger. We hypothesize… read more here.
Keywords: c2c12; inhibited c2c12; acetyl cysteine; differentiation ... See more keywords
Vitamin C Activates the Folate-Mediated One-Carbon Cycle in C2C12 Myoblasts
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DOI: 10.3390/antiox9030217
Abstract: Vitamin C (L-ascorbic acid, AA) is an essential cellular antioxidant and cofactor for several α-ketoglutarate-dependent dioxygenases. As an antioxidant, AA interacts with vitamin E to control oxidative stress. While several reports suggest an interaction of… read more here.
Keywords: folate mediated; mediated one; carbon cycle; c2c12 ... See more keywords
Regulatory Action of Plasma from Patients with Obesity and Diabetes towards Muscle Cells Differentiation and Bioenergetics Revealed by the C2C12 Cell Model and MicroRNA Analysis
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecules"
DOI: 10.3390/biom11060769
Abstract: Obesity and type 2 diabetes mellitus (T2DM) are often combined and pathologically affect many tissues due to changes in circulating bioactive molecules. In this work, we evaluated the effect of blood plasma from obese (OB)… read more here.
Keywords: plasma; muscle; c2c12; model ... See more keywords