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   Articles with "c2c12" as a keyword



Potato protein hydrolysate (PP902) inhibits dexamethasone-induced muscle atrophy by regulating MuRF1 and MAFbx expression in C2C12 myotubes in vitro.

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recommendations! Published in 2025 at "Journal of the science of food and agriculture"

DOI: 10.1002/jsfa.70371

Abstract: BACKGROUND Skeletal muscle atrophy occurs when muscle mass and strength decrease due to aging, starvation, cancer, and cachectic diseases. Recently, an increasing focus has been on investigating potato protein's nutritional and functional properties and its… read more here.

Keywords: induced muscle; muscle; muscle atrophy; pp902 ... See more keywords

A lipidomics approach reveals novel phospholipid changes in palmitate-treated C2C12 myotubes.

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recommendations! Published in 2024 at "Lipids"

DOI: 10.1002/lipd.12387

Abstract: Type 2 diabetes mellitus (T2DM) is a highly prevalent metabolic disorder. Insulin resistance and oxidative stress are associated with T2DM development. The hypothesis that patients with T2DM show excess accumulation of lipids, such as ceramides… read more here.

Keywords: novel phospholipid; lipidomics approach; reveals novel; c2c12 ... See more keywords

Poncirin, an orally active flavonoid exerts antidiabetic complications and improves glucose uptake activating PI3K/Akt signaling pathway in insulin resistant C2C12 cells with anti-glycation capacities.

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recommendations! Published in 2020 at "Bioorganic chemistry"

DOI: 10.1016/j.bioorg.2020.104061

Abstract: Poncirin, a natural flavanone glycoside present abundantly in many citrus fruits, contains an extensive range of biological activities. However, the antidiabetic mechanism of poncirin is unexplored yet. In this study, we examined the anti-diabetic prospective… read more here.

Keywords: c2c12 cells; resistant c2c12; poncirin; c2c12 ... See more keywords

Mechanisms of simvastatin myotoxicity: The role of autophagy flux inhibition.

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recommendations! Published in 2019 at "European journal of pharmacology"

DOI: 10.1016/j.ejphar.2019.172616

Abstract: Statins are some of the most widely used drugs worldwide, but one of their major side effects is myotoxicity. Using mouse myoblast (C2C12) and human alveolar rhabdomyosarcoma cell lines (RH30) in 2-dimensional (2D) and 3-dimensional… read more here.

Keywords: myotoxicity; simvastatin induced; c2c12; simvastatin myotoxicity ... See more keywords

An herbal formula consisting of Schisandra chinensis (Turcz.) Baill, Lycium chinense Mill and Eucommia ulmoides Oliv alleviates disuse muscle atrophy in rats.

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recommendations! Published in 2018 at "Journal of ethnopharmacology"

DOI: 10.1016/j.jep.2017.10.008

Abstract: ETHNOPHARMACOLOGICAL RELEVANCE Schisandra chinensis (Turcz.) Baill (SC), Lycium chinense Mill (LC) and Eucommia ulmoides Oliv (EU) are representative tonic herbal medicines that help to strengthen body muscles and bones making them stronger according to the… read more here.

Keywords: disuse muscle; formula; muscle; c2c12 ... See more keywords

ActivinA activates Notch1-Shh signaling to regulate proliferation in C2C12 skeletal muscle cells

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recommendations! Published in 2021 at "Molecular and Cellular Endocrinology"

DOI: 10.1016/j.mce.2020.111055

Abstract: The myoblast is a precursor cell that rebuilds muscle tissue after trauma in human and animal skeletal muscle tissue. Proliferation of myoblasts is important for skeletal muscle damage repair and is controlled by numerous transcription… read more here.

Keywords: skeletal muscle; shh signaling; c2c12; proliferation ... See more keywords

Corticosterone biosynthesis in mouse clonal myoblastic C2C12 cells

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recommendations! Published in 2018 at "Steroids"

DOI: 10.1016/j.steroids.2018.07.001

Abstract: Graphical abstract Figure. No Caption available. Highlights3ß‐HSD, cytochrome P450c21 and cytochrome P45011ß, exist in C2C12 cells.C2C12 cells do not reveal P450scc activity, but the cells show sulfatase activity.Cholesterol is not initial substrate for local corticosterone… read more here.

Keywords: c2c12 cells; c2c12; pregnenolone sulfate; clonal myoblastic ... See more keywords

NMR-based metabolomic analysis for the effects of creatine supplementation on mouse myoblast cell line C2C12

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recommendations! Published in 2017 at "Acta Biochimica et Biophysica Sinica"

DOI: 10.1093/abbs/gmx043

Abstract: Creatine (Cr) supplementation has drawn much attention from researchers owing to its widespread efficacy in sports, and more recently, in therapeutic fields. However, the underlying molecular mechanisms remain elusive. Here, we performed nuclear magnetic resonance-based… read more here.

Keywords: supplementation; creatine supplementation; analysis; c2c12 ... See more keywords

GNE deficiency impairs Myogenesis in C2C12 cells and cannot be rescued by ManNAc supplementation

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recommendations! Published in 2024 at "Glycobiology"

DOI: 10.1093/glycob/cwae004

Abstract: Abstract GNE myopathy (GNEM) is a late-onset muscle atrophy, caused by mutations in the gene for the key enzyme of sialic acid biosynthesis, UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE). With an incidence of one to nine cases… read more here.

Keywords: supplementation; myogenesis c2c12; gne; c2c12 ... See more keywords

Genome-wide survey reveals dynamic effects of folate supplement on DNA methylation and gene expression during C2C12 differentiation.

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recommendations! Published in 2018 at "Physiological genomics"

DOI: 10.1152/physiolgenomics.00094.2017

Abstract: Folic acid supplements taken during pregnancy can prevent neural tube defects and other developmental abnormalities. Here, we explored the effects of folate supplementation on gene expression and DNA methylation during C2C12 differentiation. Based on the… read more here.

Keywords: methylation; c2c12; expression; differentiation ... See more keywords

Bis-Indole–Derived NR4A1 Ligands and Metformin Exhibit NR4A1-Dependent Glucose Metabolism and Uptake in C2C12 Cells

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recommendations! Published in 2018 at "Endocrinology"

DOI: 10.1210/en.2017-03049

Abstract: Treatment of C2C12 muscle cells with metformin or the NR4A1 ligand 1,1-bis(3'-indolyl)-1-(p-hydroxyphenyl)methane (DIM-C-pPhOH) induced NR4A1 and Glut4 messenger RNA and protein expression. Similar results were observed with buttressed (3- or 3,5-substituted) analogs of DIM-C-pPhOH, including… read more here.

Keywords: c2c12 cells; nr4a1 ligands; uptake c2c12; bis indole ... See more keywords