Poncirin, an orally active flavonoid exerts antidiabetic complications and improves glucose uptake activating PI3K/Akt signaling pathway in insulin resistant C2C12 cells with anti-glycation capacities.
Sign Up to like & getrecommendations! Published in 2020 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2020.104061
Abstract: Poncirin, a natural flavanone glycoside present abundantly in many citrus fruits, contains an extensive range of biological activities. However, the antidiabetic mechanism of poncirin is unexplored yet. In this study, we examined the anti-diabetic prospective… read more here.
Keywords: c2c12 cells; resistant c2c12; poncirin; c2c12 ... See more keywords
PI3K/AKT signaling pathway involvement in fluoride-induced apoptosis in C2C12 cells.
Sign Up to like & getrecommendations! Published in 2018 at "Chemosphere"
DOI: 10.1016/j.chemosphere.2018.02.057
Abstract: To investigate the mechanisms of fluoride-induced apoptosis, a fluoride-induced C2C12 skeletal muscle cell (C2C12 cell) model was established in this study, and the viability of the C2C12 cells was measured using an MTT assay. Cell morphological changes… read more here.
Keywords: fluoride induced; c2c12 cells; induced apoptosis;
Corticosterone biosynthesis in mouse clonal myoblastic C2C12 cells
Sign Up to like & getrecommendations! Published in 2018 at "Steroids"
DOI: 10.1016/j.steroids.2018.07.001
Abstract: Graphical abstract Figure. No Caption available. Highlights3ß‐HSD, cytochrome P450c21 and cytochrome P45011ß, exist in C2C12 cells.C2C12 cells do not reveal P450scc activity, but the cells show sulfatase activity.Cholesterol is not initial substrate for local corticosterone… read more here.
Keywords: c2c12 cells; c2c12; pregnenolone sulfate; clonal myoblastic ... See more keywords
Non-Smad, BMP-dependent signaling protects against the effects of acute ethanol toxicity.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2021.10.009
Abstract: This study explores the effect of acute Ethanol (EtOH) exposure on Bone Morphogenetic Protein (BMP)-evoked intracellular signaling, and the concomitant morphological changes induced by EtOH in C2C12 cells and DRG (Dorsal root ganglion) neurons in… read more here.
Keywords: c2c12 cells; etoh exposure; bmp; exposure ... See more keywords
Hematite iron oxide nanoparticles: apoptosis of myoblast cancer cells and their arithmetical assessment
Sign Up to like & getrecommendations! Published in 2018 at "RSC Advances"
DOI: 10.1039/c8ra02613k
Abstract: Hematite (α-Fe2O3) forms iron oxide nanoparticles (NPs) which are thermally stable and have various electrochemical and optochemical applications. Due to their wide applicability, the present work was designed to form the hematite phase of iron… read more here.
Keywords: c2c12 cells; nanoparticles apoptosis; hematite iron; iron oxide ... See more keywords
MiR-128 inhibits the osteogenic differentiation in osteoporosis by down-regulating SIRT6 expression
Sign Up to like & getrecommendations! Published in 2019 at "Bioscience Reports"
DOI: 10.1042/bsr20191405
Abstract: Background: MicroRNAs (miRNAs) are involved in the regulation of osteogenic differentiation and chondrification in vivo. The purpose of the present study was to explore the potential mechanism of miR-128 in osteoporosis (OP). Methods: Quantitative real-time… read more here.
Keywords: expression; osteogenic differentiation; c2c12 cells; differentiation ... See more keywords
Bis-Indole–Derived NR4A1 Ligands and Metformin Exhibit NR4A1-Dependent Glucose Metabolism and Uptake in C2C12 Cells
Sign Up to like & getrecommendations! Published in 2018 at "Endocrinology"
DOI: 10.1210/en.2017-03049
Abstract: Treatment of C2C12 muscle cells with metformin or the NR4A1 ligand 1,1-bis(3'-indolyl)-1-(p-hydroxyphenyl)methane (DIM-C-pPhOH) induced NR4A1 and Glut4 messenger RNA and protein expression. Similar results were observed with buttressed (3- or 3,5-substituted) analogs of DIM-C-pPhOH, including… read more here.
Keywords: c2c12 cells; nr4a1 ligands; uptake c2c12; bis indole ... See more keywords
1946-P: Insulin-Like Growth Factor-1 Protects against the Detrimental Effects of Advanced Glycation End Products and High Glucose in Myoblastic C2C12 Cells
Sign Up to like & getrecommendations! Published in 2019 at "Diabetes"
DOI: 10.2337/db19-1946-p
Abstract: Previous studies have shown that diabetes mellitus increases the risk of sarcopenia. We previously reported that higher serum advanced glycation end product (AGE) and lower serum insulin-like growth factor-I (IGF-I) were independently associated with muscle… read more here.
Keywords: c2c12 cells; none; apoptosis; advanced glycation ... See more keywords
Sumoylation-deficient phosphoglycerate mutase 2 impairs myogenic differentiation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.1052363
Abstract: Phosphoglycerate mutase 2 (PGAM2) is a critical glycolytic enzyme that is highly expressed in skeletal muscle. In humans, naturally occurring mutations in Phosphoglycerate mutase 2 have been etiologically linked to glycogen storage disease X (GSDX).… read more here.
Keywords: mutase; sumoylation; differentiation; c2c12 cells ... See more keywords
Conditions Inducing Excessive O-GlcNAcylation Inhibit BMP2-Induced Osteogenic Differentiation of C2C12 Cells
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19010202
Abstract: Hyperglycemic conditions in diabetic patients can affect various cellular functions, including the modulation of osteogenic differentiation. However, the molecular mechanisms by which hyperglycemia affects osteogenic differentiation are yet to be clarified. This study aimed to… read more here.
Keywords: protein; c2c12 cells; glcnacylation; osteogenic differentiation ... See more keywords
miR-103-3p Regulates the Differentiation and Autophagy of Myoblasts by Targeting MAP4
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24044130
Abstract: Skeletal muscle is the most abundant tissue in mammals, and myogenesis and differentiation require a series of regulatory factors such as microRNAs (miRNAs). In this study, we found that miR-103-3p was highly expressed in the… read more here.
Keywords: differentiation; c2c12 cells; mir 103; differentiation autophagy ... See more keywords