TSC2/Rheb signaling mediates ERK‐dependent regulation of mTORC1 activity in C2C12 myoblasts
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DOI: 10.1002/2211-5463.12195
Abstract: The enhanced rate of protein synthesis in skeletal muscle cells results in a net increase in total protein content that leads to skeletal muscle growth/hypertrophy. The mitogen‐activated protein kinase kinase (MEK)/extracellular signal‐regulated kinase (ERK)‐dependent regulation… read more here.
Keywords: c2c12 myoblasts; mtorc1; activation; erk dependent ... See more keywords
l-Citrulline prevents heat-induced mitochondrial dysfunction and cell injury through nitric oxide-mediated Drp1 inhibition in mouse C2C12 myoblasts
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DOI: 10.1017/s0007114522001982
Abstract: Abstract Severe heat exposure causes mitochondrial fragmentation and dysfunction, which contribute to the pathogenesis of heat-related illness. l-Citrulline is a naturally occurring amino acid and has been suggested to influence heat shock responses. This study… read more here.
Keywords: cell; citrulline; heat induced; dysfunction ... See more keywords
Honokiol ameliorates oxidative stress-induced DNA damage and apoptosis of c2c12 myoblasts by ROS generation and mitochondrial pathway
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DOI: 10.1080/19768354.2019.1706634
Abstract: ABSTRACT Honokiol is one of the main active components of Magnolia officinalis, and has been demonstrated to have multiple pharmacological activities against a variety of diseases. Recently, this phenolic compound is known to have antioxidant… read more here.
Keywords: induced dna; dna damage; damage apoptosis; c2c12 myoblasts ... See more keywords
Lipopolysaccharide inhibits myogenic differentiation of C2C12 myoblasts through the Toll-like receptor 4-nuclear factor-κB signaling pathway and myoblast-derived tumor necrosis factor-α
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DOI: 10.1371/journal.pone.0182040
Abstract: Background Circulating lipopolysaccharide (LPS) concentrations are often elevated in patients with sepsis or with various endogenous diseases that are associated with metabolic endotoxemia. Involuntary loss of skeletal muscle, termed muscle wasting, is commonly observed in… read more here.
Keywords: toll like; myogenic differentiation; muscle; c2c12 myoblasts ... See more keywords
NMR-Based Metabolomic Analysis for the Effects of Trimethylamine N-Oxide Treatment on C2C12 Myoblasts under Oxidative Stress
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DOI: 10.3390/biom12091288
Abstract: The gut microbial metabolite trimethylamine N-oxide (TMAO) has received increased attention due to its close relationship with cardiovascular disease and type 2 diabetes. In previous studies, TMAO has shown both harmful and beneficial effects on… read more here.
Keywords: tmao treatment; oxidative stress; trimethylamine oxide; c2c12 myoblasts ... See more keywords
The TRPV1 Receptor Is Up-Regulated by Sphingosine 1-Phosphate and Is Implicated in the Anandamide-Dependent Regulation of Mitochondrial Activity in C2C12 Myoblasts
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DOI: 10.3390/ijms231911103
Abstract: The sphingosine 1-phosphate (S1P) and endocannabinoid (ECS) systems comprehend bioactive lipids widely involved in the regulation of similar biological processes. Interactions between S1P and ECS have not been so far investigated in skeletal muscle, where… read more here.
Keywords: trpv1 receptor; regulation; c2c12 myoblasts; sphingosine phosphate ... See more keywords
Clenbuterol Induces Cell Cycle Arrest in C2C12 Myoblasts by Delaying p27 Degradation through β-arrestin 2 Signaling
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DOI: 10.7150/ijbs.17948
Abstract: β2-Adrenoceptor (β2-AR) agonists promote muscle growth. The aim of this study was to elucidate some effects of the selective β2-adrenoceptor agonist clenbuterol (CLB) on myoblast proliferation. We found that CLB induces cell cycle arrest in… read more here.
Keywords: cycle arrest; induces cell; c2c12 myoblasts; cell cycle ... See more keywords
Inhibition of Lipopolysaccharide-Induced Inflammatory and Oxidative Responses by Trans-cinnamaldehyde in C2C12 Myoblasts
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DOI: 10.7150/ijms.59169
Abstract: Background: Trans-cinnamaldehyde (tCA), a bioactive component found in Cinnamomum cassia, has been reported to exhibit anti-inflammatory and antioxidant effects, but its efficacy in muscle cells has yet to be found. In this study, we investigated… read more here.
Keywords: trans cinnamaldehyde; c2c12 myoblasts; expression; tca ... See more keywords