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The Pore-Forming Subunit C2IIa of the Binary Clostridium botulinum C2 Toxin Reduces the Chemotactic Translocation of Human Polymorphonuclear Leukocytes

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Published in 2022 at "Frontiers in Pharmacology"

DOI: 10.3389/fphar.2022.810611

Abstract: The binary C2 toxin of Clostridium (C.) botulinum consists of two non-linked proteins, the enzyme subunit C2I and the separate binding/transport subunit C2II. To exhibit toxic effects on mammalian cells, proteolytically activated C2II (C2IIa) forms… read more here.

Keywords: clostridium botulinum; c2iia; microscopy; toxin ... See more keywords