Mice lacking gamma ENaC palmitoylation sites maintain amiloride/benzamil-sensitive Na+ transport in vivo, despite markedly reduced open probability of typical ENaC-like channels.
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DOI: 10.1152/physiol.2023.38.s1.5729916
Abstract: Background: Epithelial Na+ channels (ENaCs) play a major role in controlling extracellular fluid volume and electrolyte homeostasis by facilitating absorption of Na+ across transporting epithelia, such as the kidney and distal colon. ENaCs are heterotrimeric… read more here.
Keywords: enac; physiology; palmitoylation; enac c33a ... See more keywords