Effective inhibition of C3a-mediated pro-inflammatory response by a human C3a-specific protein binder.
Sign Up to like & getrecommendations! Published in 2020 at "Biotechnology and bioengineering"
DOI: 10.1002/bit.27309
Abstract: Complement component 3a (C3a) plays a crucial role in the immune response and host defense, but it is also involved in pro-inflammatory responses, causing many inflammatory disorders. Blockade of C3a has been regarded as a… read more here.
Keywords: c3a; protein binder; response; specific protein ... See more keywords
Quantification of Porcine Complement Activation Fragment C3a by a Neoepitope-Based Enzyme-Linked Immunosorbent Assay.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1016-9_5
Abstract: Enzyme-linked immunosorbent assay (ELISA) enables fast and simple quantification of analytes in the pico- to nanogram range in complex samples. Here, we describe an ELISA for the detection of porcine C3a as a marker for… read more here.
Keywords: c3a; linked immunosorbent; immunosorbent assay; complement activation ... See more keywords
The role of sulfate ions in tricalcium aluminate hydration: New insights
Sign Up to like & getrecommendations! Published in 2020 at "Cement and Concrete Research"
DOI: 10.1016/j.cemconres.2020.105973
Abstract: Abstract As a major mineral of Portland cement, the hydration of tricalcium aluminate (C3A) has a significant impact on various properties of cement-based materials. However, there is little consensus on its mechanism, especially the interaction… read more here.
Keywords: c3a; sulfate ions; tricalcium aluminate; role sulfate ... See more keywords
Effect of seawater as mixing water on the hydration behaviour of tricalcium aluminate
Sign Up to like & getrecommendations! Published in 2021 at "Cement and Concrete Research"
DOI: 10.1016/j.cemconres.2021.106565
Abstract: Abstract This study explored the mechanism of the effect of seawater on tricalcium aluminate (C3A) hydration. The results showed that seawater retarded C3A hydration and reduced the reaction degree of C3A. The co-existence or ion… read more here.
Keywords: effect seawater; c3a; tricalcium aluminate; hydration ... See more keywords
Potent Thiophene Antagonists of Human Complement C3a Receptor with Anti-Inflammatory Activity.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b00927
Abstract: Structure-activity relationships for a series of small-molecule thiophenes resulted in potent and selective antagonism of human Complement C3a receptor. The compounds are about 100-fold more potent than the most reported antagonist SB290157. A new compound… read more here.
Keywords: c3a; c3a receptor; activity; human complement ... See more keywords
C3a is required for ILC2 function in allergic airway inflammation
Sign Up to like & getrecommendations! Published in 2018 at "Mucosal immunology"
DOI: 10.1038/s41385-018-0064-x
Abstract: Aberrant type 2 responses underlie the pathologies in allergic diseases like asthma, yet, our understanding of the mechanisms that drive them remains limited. Recent evidence suggests that dysregulated innate immune factors can perpetuate asthma pathogenesis.… read more here.
Keywords: innate; c3a; inflammation; c3a required ... See more keywords
Investigating the hydration of C3A in the presence of the potentially toxic element chromium–a route to remediation?
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra04497h
Abstract: Pollution by hexavalent chromium is a growing, global problem. Its presence in public water systems is often the result of industrial activities, both past and present. In this study, tricalcium aluminate (C3A, Ca3Al2O6) is added… read more here.
Keywords: presence; c3a; ppm; remediation ... See more keywords
C3a receptor blockade protects podocytes from injury in diabetic nephropathy.
Sign Up to like & getrecommendations! Published in 2020 at "JCI insight"
DOI: 10.1172/jci.insight.131849
Abstract: Renal activation of the complement system has been described in patients with diabetic nephropathy (DN), although its pathological relevance is still ill-defined. Here, we studied whether glomerular C3a, generated by uncontrolled complement activation, promotes podocyte… read more here.
Keywords: c3a receptor; c3a; blockade; diabetic nephropathy ... See more keywords
Optimization of decellularized liver matrix-modified chitosan fibrous scaffold for C3A hepatocyte culture
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Biomaterials Applications"
DOI: 10.1177/08853282221115367
Abstract: Hepatocyte scaffold is an essential part in bioartificial liver device. We have designed a novel hepatocyte scaffold based on porcine liver extracellular matrix (ECM) and chitosan (CTS) fabrics. This CTS-ECM scaffold can improve cell adhesion… read more here.
Keywords: c3a; cts ecm; scaffold; concentration edc ... See more keywords
Urinary C3 levels associated with sepsis and acute kidney injury—A pilot study
Sign Up to like & getrecommendations! Published in 2021 at "PLoS ONE"
DOI: 10.1371/journal.pone.0259777
Abstract: Acute kidney injury (AKI) is an abrupt deterioration of renal function often caused by severe clinical disease such as sepsis, and patients require intensive care. Acute-phase parameters for systemic inflammation are well established and used… read more here.
Keywords: sepsis; c3a; kidney injury; acute kidney ... See more keywords
C3aR plays both sides in regulating resistance to bacterial infections
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010657
Abstract: Activation of the complement pathway results in the production of bioactive C3a, a product of C3 cleavage, which interacts with membrane-bound receptor C3aR to regulate innate immune cell function and outcome of bacterial infection. Specifically,… read more here.
Keywords: cell; c3a; bacterial infections; c3ar ... See more keywords