Targeting Complement C3a Receptor to Improve Outcome After Ischemic Brain Injury
Sign Up to like & getrecommendations! Published in 2021 at "Neurochemical Research"
DOI: 10.1007/s11064-021-03419-6
Abstract: Ischemic stroke is a major cause of disability. No efficient therapy is currently available, except for the removal of the occluding blood clot during the first hours after symptom onset. Loss of function after stroke… read more here.
Keywords: c3a receptor; improve outcome; outcome; outcome ischemic ... See more keywords
Complement C3a receptor antagonist attenuates tau hyperphosphorylation via glycogen synthase kinase 3&bgr; signaling pathways
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2019.02.020
Abstract: ABSTRACT Neurofibrillary tangles aggregated from hyperphosphorylated tau protein are the main pathological feature of Alzheimer's disease (AD). Complement C3 (or C3a) is the core component of the complement system and is associated with AD pathological… read more here.
Keywords: receptor; c3a receptor; bgr; complement c3a ... See more keywords
A complement-microglial axis driving inhibitory synapse related protein loss might contribute to systemic inflammation-induced cognitive impairment.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106814
Abstract: Systemic inflammation induces cognitive impairments via unclear mechanisms. Increasing evidence has suggested complement C3/C3a receptor signaling, a key component of innate immune pathogen defense, plays an important role in cognition and neurodegeneration, whereas its dysfunction… read more here.
Keywords: c3a receptor; synapse related; inflammation; induced cognitive ... See more keywords
Potent Thiophene Antagonists of Human Complement C3a Receptor with Anti-Inflammatory Activity.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b00927
Abstract: Structure-activity relationships for a series of small-molecule thiophenes resulted in potent and selective antagonism of human Complement C3a receptor. The compounds are about 100-fold more potent than the most reported antagonist SB290157. A new compound… read more here.
Keywords: c3a; c3a receptor; activity; human complement ... See more keywords
C3a receptor antagonist therapy is protective with or without thrombolysis in murine thromboembolic stroke
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DOI: 10.1111/bph.14989
Abstract: Intravenous thrombolysis (IVT) after stroke enhances C3a generation, which may abrogate the benefits of reperfusion. The C3aR antagonist SB290157 is neuroprotective following transient but not permanent middle cerebral artery occlusion (MCAo). SB290157 remains untested in… read more here.
Keywords: receptor antagonist; c3a receptor; therapy protective; thrombolysis ... See more keywords
C3a receptor blockade protects podocytes from injury in diabetic nephropathy.
Sign Up to like & getrecommendations! Published in 2020 at "JCI insight"
DOI: 10.1172/jci.insight.131849
Abstract: Renal activation of the complement system has been described in patients with diabetic nephropathy (DN), although its pathological relevance is still ill-defined. Here, we studied whether glomerular C3a, generated by uncontrolled complement activation, promotes podocyte… read more here.
Keywords: c3a receptor; c3a; blockade; diabetic nephropathy ... See more keywords
Complement C3a receptor inactivation attenuates retinal degeneration induced by oxidative damage
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.951491
Abstract: Retinal degeneration causes vision loss and threatens the health of elderly individuals worldwide. Evidence indicates that the activation of the complement system is associated with retinal degeneration. However, the mechanism of complement signaling in retinal… read more here.
Keywords: degeneration; retinal degeneration; complement; c3ar1 ... See more keywords