The neuropeptide TLQP-21 opposes obesity via C3aR1-mediated enhancement of adrenergic-induced lipolysis
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Metabolism"
DOI: 10.1016/j.molmet.2016.10.005
Abstract: Objectives Obesity is characterized by excessive fat mass and is associated with serious diseases such as type 2 diabetes. Targeting excess fat mass by sustained lipolysis has been a major challenge for anti-obesity therapies due… read more here.
Keywords: c3ar1; lipolysis; induced lipolysis; obesity ... See more keywords
Absence of recipient C3aR1 signaling limits expansion and differentiation of alloreactive CD8+ T cell immunity and prolongs murine cardiac allograft survival
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DOI: 10.1111/ajt.15222
Abstract: Activation, differentiation, and expansion of alloreactive CD8+ T cells, the dominant effectors that mediate murine heart allograft rejection, requires allorecognition, costimulation, and cytokine‐initiated signals. While previous work showed that alloreactive CD4+ T cell immunity entails… read more here.
Keywords: expansion; c3ar1; allograft; alloreactive cd8 ... See more keywords
Complement C3a receptor inactivation attenuates retinal degeneration induced by oxidative damage
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.951491
Abstract: Retinal degeneration causes vision loss and threatens the health of elderly individuals worldwide. Evidence indicates that the activation of the complement system is associated with retinal degeneration. However, the mechanism of complement signaling in retinal… read more here.
Keywords: degeneration; retinal degeneration; complement; c3ar1 ... See more keywords