Induction of alopecia areata in C3H/HeJ mice using cryopreserved lymphocytes.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of dermatological science"
DOI: 10.1016/j.jdermsci.2021.04.009
Abstract: BACKGROUND Alopecia areata (AA) is an autoimmune disease resulting in non-scarring hair loss. Animal models are useful means to identify candidates for therapeutic agents. The C3H/HeJ mouse AA model induced via transferring cultured lymphoid cells… read more here.
Keywords: alopecia areata; using cryopreserved; c3h hej; cryopreserved lymphocytes ... See more keywords
Impaired autophagy promotes hair loss in the C3H/HeJ mouse model of alopecia areata
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2074104
Abstract: ABSTRACT Alopecia areata (AA) involves an aberrant immune attack on the hair follicle (HF), which leads to hair loss. Previous genetic data from our lab pointed to a connection between macroautophagy/autophagy and AA pathogenesis, and… read more here.
Keywords: hej mouse; c3h hej; impaired autophagy; hair loss ... See more keywords
Blockade of IL-7 signaling suppresses inflammatory responses and reverses alopecia areata in C3H/HeJ mice
Sign Up to like & getrecommendations! Published in 2021 at "Science Advances"
DOI: 10.1126/sciadv.abd1866
Abstract: Blocking the overexpression of IL-7 in lesional alopecis skin can reverse alopecia areata in C3H/HeJ mice. The interleukin-7 (IL-7) signaling pathway plays an important role in regulation of T cell function and survival. We detected… read more here.
Keywords: alopecia areata; hej mice; areata c3h; c3h hej ... See more keywords
Generalized resistance to pruritogen-induced scratching in the C3H/HeJ strain
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.934564
Abstract: Previously the effect of the pruritogens, such as histamine and chloroquine, was tested in 11 inbred mouse strains, and this study aimed to identify resistant and sensitive strains, consistent with the observation that underlies the… read more here.
Keywords: pruritogen; c3h hej; strain; resistance ... See more keywords