Genetically Predicted Brain C4A Expression Is Associated With TSPO and Hippocampal Morphology
Sign Up to like & getrecommendations! Published in 2021 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2021.06.021
Abstract: BACKGROUND Alterations in the immune system, particularly C4A, have been implicated in the pathophysiology of schizophrenia. C4A promotes synapse elimination by microglia in preclinical models; however, it is unknown whether this process is also present… read more here.
Keywords: c4a; c4a expression; brain c4a; genetically predicted ... See more keywords
Comprehensive approach to study complement C4 in systemic lupus erythematosus: Gene polymorphisms, protein levels and functional activity
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Immunology"
DOI: 10.1016/j.molimm.2017.10.004
Abstract: HighlightsLow gene copy number of C4A is associated with increased susceptibility to SLE.Serositis is associated with low gene copy number of C4A in SLE patients.A basepair insertion (A) after A1112 causes a silencing mutation in… read more here.
Keywords: binding capacity; c4a; sle; systemic lupus ... See more keywords
QM/MM Molecular Modeling Reveals Mechanism Insights into Flavin Peroxide Formation in Bacterial Luciferase
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.1c01187
Abstract: Bacterial luciferase (Lux) catalyzes oxidation of reduced flavin mononucleotide (FMN) and aldehyde to form oxidized FMN and carboxylic acid via molecular oxygen with concomitant light generation. The enzyme is useful for various detection applications in… read more here.
Keywords: luciferase; c4a; fmnh c4a; mechanism ... See more keywords