Genetically Predicted Brain C4A Expression Is Associated With TSPO and Hippocampal Morphology
Sign Up to like & getrecommendations! Published in 2021 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2021.06.021
Abstract: BACKGROUND Alterations in the immune system, particularly C4A, have been implicated in the pathophysiology of schizophrenia. C4A promotes synapse elimination by microglia in preclinical models; however, it is unknown whether this process is also present… read more here.
Keywords: c4a; c4a expression; brain c4a; genetically predicted ... See more keywords
SA91 INCREASED PREDICTED C4A EXPRESSION IS ASSOCIATED WITH COGNITIVE DEFICIT IN BOTH SCHIZOPHRENIA AND ALZHEIMER'S DISEASE
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.163
Abstract: Background Recently, Sekar et al. (Nature, 2016) reported that the top GWAS hit for schizophrenia in the Major Histocompatibility Complex (MHC) locus implicated structural variants in the C4 gene which are associated with C4A expression… read more here.
Keywords: alzheimer disease; schizophrenia; c4a expression; expression ... See more keywords