Mesangial C4d deposition may predict progression of kidney disease in pediatric patients with IgA nephropathy
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DOI: 10.1007/s00467-017-3610-y
Abstract: BackgroundData on the risk factors for chronic kidney disease in children with immunoglobulin A nephropathy (IgAN) are scarce. This study was aimed at investigating whether glomerular C4d immunostaining is a prognostic marker in pediatric IgAN.MethodsIn… read more here.
Keywords: c4d deposition; kidney disease; c4d; mesangial c4d ... See more keywords
Noninvasive quantification of intrarenal allograft C4d deposition with targeted ultrasound imaging
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DOI: 10.1111/ajt.15105
Abstract: Antibody‐mediated rejection (AMR) has emerged as a major cause of renal allograft dysfunction. C4d, a specific marker for AMR diagnosis, was strongly recommended for routine surveillance; however, currently, C4d detection is dependent upon tissue biopsy,… read more here.
Keywords: ultrasound imaging; c4d; allograft; targeted ultrasound ... See more keywords
Patterns of Interferon γ Expression and C4d Deposition in Chronic Intervillositis of Unknown Etiology
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DOI: 10.1177/10935266221144083
Abstract: The pathogenesis of chronic intervillositis of unknown etiology (CIUE) may involve IFNγ overexpression. This study assesses the extent of IFNγ expression in CIUE by immunohistochemistry and compares it to spontaneous pregnancy losses. C4d deposition is… read more here.
Keywords: ciue; etiology; c4d deposition; expression ... See more keywords
Clinical significance of C4d deposition in renal tissues from patients with primary Sjögren’s syndrome—a preliminary study
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DOI: 10.1186/s12882-019-1341-y
Abstract: BackgroundTo evaluate renal expression of C4d, a complement component in the classical/mannose binding lectin (MBL) pathway, in patients with primary Sjögren’s syndrome (pSS)-associated renal impairments.MethodsWe retrospectively reviewed the clinical and pathological data from 39 patients… read more here.
Keywords: gren syndrome; c4d; deposition; primary gren ... See more keywords
C4d as a Screening Tool and an Independent Predictor of Clinical Outcomes in Lupus Nephritis and IgA Nephropathy
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DOI: 10.3389/fmed.2022.832998
Abstract: Background As an indispensable marker of complement cascades activation, C4d was confirmed of its crucial role in the pathogenesis of both lupus nephritis (LN) and IgA nephropathy (IgAN). While the studies directly comparing the diagnostic… read more here.
Keywords: disease; igan patients; renal c4d; c4d deposition ... See more keywords