Multi‐omics analysis reveals expression complexity and functional diversity of mouse kinome
Sign Up to like & getrecommendations! Published in 2022 at "PROTEOMICS"
DOI: 10.1002/pmic.202200120
Abstract: Protein kinases are a crucial component of signaling pathways involved in a wide range of cellular responses, including growth, proliferation, differentiation, and migration. Systematic investigation of protein kinases is critical to better understand phosphorylation‐mediated signaling… read more here.
Keywords: multi omics; protein kinases; c57bl; analysis ... See more keywords
Mild reproductive impact of a Y chromosome deletion on a C57BL/6J substrain
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DOI: 10.1007/s00335-017-9680-0
Abstract: A recently reported deletion of about 40 Mb in length between 6.12/6.57 and 46.73/47.31 Mb on the Y chromosome long arm of the C57BL/6JBomTac inbred strain made us closely examine the strain’s breeding history and reproductive characteristics.… read more here.
Keywords: c57bl substrain; c57bl 6jbomtac; mild reproductive; deletion ... See more keywords
The effect of the demyelinating agent cuprizone on binge-like eating of sweetened palatable food in female and male C57BL/6 substrains
Sign Up to like & getrecommendations! Published in 2020 at "Appetite"
DOI: 10.1016/j.appet.2020.104678
Abstract: Binge eating (BE) is a heritable symptom of eating disorders with an unknown genetic etiology. Rodent models for binge-like eating (BLE) of palatable food permit the study of genetic and biological mechanisms. We previously genetically… read more here.
Keywords: palatable food; cuprizone; effect; c57bl ... See more keywords
Age-related cognitive decline in spatial learning and memory of C57BL/6J mice
Sign Up to like & getrecommendations! Published in 2022 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2021.113649
Abstract: During the last decades, most of the preclinical neurodegenerative research was performed in mouse models of amyloidosis, tauopathies or α-synucleinopathies preferentially maintained on a C57BL/6J background. However, comprehensive neurobehavioural data from C57BL/6J mice outlining the… read more here.
Keywords: c57bl mice; spatial learning; age; c57bl ... See more keywords
Differential metabolic and inflammatory responses to intermittent hypoxia in substrains of lean and obese C57BL/6 mice.
Sign Up to like & getrecommendations! Published in 2019 at "Life sciences"
DOI: 10.1016/j.lfs.2019.116959
Abstract: AIMS This study was to investigate the degree of susceptibility to intermittent hypoxia (IH), a hallmark of obstructive sleep apnea (OSA), between the two mice inbred lines C57BL/6N (6N) and C57BL/6J (6J). MATERIALS AND METHODS… read more here.
Keywords: inflammatory responses; metabolic inflammatory; c57bl mice; c57bl ... See more keywords
Elevated Oxidative Stress Impairs Hematopoietic Progenitor Function in C57BL/6 Substrains
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DOI: 10.1016/j.stemcr.2018.06.011
Abstract: Summary C57BL/6N (N) and C57BL/6J (J) mice possess key genetic differences, including a deletion in the Nicotinamide nucleotide transhydrogenase (Nnt) gene that results in a non-functional protein in J mice. NNT regulates mitochondrial oxidative stress.… read more here.
Keywords: function; c57bl; stress; hspcs ... See more keywords
Strain‐related differences in mouse lung gene expression over a two‐year period of inhalation exposure to styrene: Relevance to human risk assessment
Sign Up to like & getrecommendations! Published in 2018 at "Regulatory Toxicology and Pharmacology"
DOI: 10.1016/j.yrtph.2018.05.011
Abstract: ABSTRACT Both CD‐1 and C57BL/6 wildtype (C57BL/6‐WT) mice show equivalent short‐term lung toxicity from exposures to styrene, while long‐term tumor responses are greater in CD‐1 mice. We analyzed lung gene expression from styrene exposures lasting… read more here.
Keywords: gene expression; c57bl; term; mice ... See more keywords
A comparative analysis of hepatic pathological phenotypes in C57BL/6J and C57BL/6N mouse strains in non-alcoholic steatohepatitis models
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DOI: 10.1038/s41598-018-36862-7
Abstract: C57BL/6J (BL6J) and C57BL/6N (BL6N) inbred substrains are most widely used to understand the pathological roles of target molecules in a variety of diseases, including non-alcoholic steatohepatitis (NASH), based on transgenic mouse technologies. There are… read more here.
Keywords: comparative analysis; non alcoholic; alcoholic steatohepatitis; c57bl ... See more keywords
Aging influence on pulmonary and systemic inflammation and neural metabolomics arising from pulmonary multi-walled carbon nanotube exposure in apolipoprotein E-deficient and C57BL/6 female mice
Sign Up to like & getrecommendations! Published in 2022 at "Inhalation Toxicology"
DOI: 10.1080/08958378.2022.2026538
Abstract: Abstract Objective Environmental exposures exacerbate age-related pathologies, such as cardiovascular and neurodegenerative diseases. Nanoparticulates, and specifically carbon nanomaterials, are a fast-growing contributor to the category of inhalable pollutants, whose risks to health are only now… read more here.
Keywords: carbon nanotube; c57bl; mwcnt exposure; mice ... See more keywords
The genetic difference between C57Bl/6J and C57Bl/6N mice significantly impacts Aldara™‐induced psoriasiform dermatitis
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Dermatology"
DOI: 10.1111/exd.13131
Abstract: Since its first description in 2009,1 the AldaraTM (MEDA Pharma GmbH, Bad Homburg, Germany)-induced psoriasiform dermatitis (AIPD) model has become a most commonly used mouse model of plaque psoriasis. It is mostly conducted in the… read more here.
Keywords: c57bl c57bl; c57bl mice; psoriasiform dermatitis; induced psoriasiform ... See more keywords
Cerebral Malaria Is Regulated by Host-Mediated Changes in Plasmodium Gene Expression
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DOI: 10.1128/mbio.03391-22
Abstract: Hundreds of thousands of lives are lost each year due to the brain damage caused by malaria disease. The overwhelming majority of these deaths occur in young children living in sub-Saharan Africa. ABSTRACT Cerebral malaria… read more here.
Keywords: anka; host; c57bl; gene expression ... See more keywords