Pharmacological inhibition of the primary endocannabinoid producing enzyme, DGL‐α, induces autism spectrum disorder‐like and co‐morbid phenotypes in adult C57BL/J mice
Sign Up to like & getrecommendations! Published in 2021 at "Autism Research"
DOI: 10.1002/aur.2520
Abstract: Accumulating evidence links dysfunction in the endocannabinoid system (ECS) with the pathology of neurodevelopmental disorders, particularly autism spectrum disorder (ASD). Variants in ECS genes CNR1 and DAGLA are associated with neurological phenotypes in humans. The… read more here.
Keywords: endocannabinoid; c57bl mice; enzyme dgl; spectrum disorder ... See more keywords
Noncoding RNA 886 alleviates tumor cellular immunological rejection in host C57BL/C mice
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.3148
Abstract: Non‐coding RNA 886 (nc886/VTRNA2‐1) is a Pol III transcript and an atypical imprinted gene. Its exact function as a negative regulator of protein kinase R establishes its connection with innate immunity. Studies have shown that… read more here.
Keywords: rejection; rna 886; host; c57bl mice ... See more keywords
Assessing the genotoxicity of N‐nitrosodiethylamine with three in vivo endpoints in male Big Blue® transgenic and wild‐type C57BL/6N mice
Sign Up to like & getrecommendations! Published in 2024 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22615
Abstract: The detection of N‐nitrosamines in drug products has raised global regulatory interest in recent years due to the carcinogenic potential of some nitrosamines in animals and a need to identify a testing strategy has emerged.… read more here.
Keywords: mice; c57bl mice; three vivo; big blue ... See more keywords
Gasoline fume inhalation induces apoptosis, inflammation, and favors Th2 polarization in C57BL/6 mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4286
Abstract: Gasoline exposure has been widely reported in the literature as being toxic to human health. However, the exact underlying molecular mechanisms triggered by its inhalation have not been thoroughly investigated. We herein present a model… read more here.
Keywords: gasoline fume; gasoline; inhalation; c57bl mice ... See more keywords
Tributyltin induces distinct effects on cortical and trabecular bone in female C57Bl/6J mice
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26495
Abstract: The retinoid X receptors (RXR), peroxisome proliferator activated receptor gamma (PPARγ), and liver X receptors (LXR) all have been shown to regulate bone homeostasis. Tributyltin (TBT) is an environmental contaminant that is a dual RXRα/β… read more here.
Keywords: c57bl mice; female c57bl; bone; effects cortical ... See more keywords
Breaching bacterial biofilm with neutrophil α‐mannosidase
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.4ce0419-139r
Abstract: In the current issue of Journal of Leukocyte Biology, Kugadas et al.1 examined a murine model of Pseudomonas aeruginosa infection of the cornea where the bacteria produce an exo-polysaccharide biofilm. These investigators demonstrated that outbred… read more here.
Keywords: c57bl mice; mice; outbred mice; biology ... See more keywords
Inter‐breeder differences in prepulse inhibition deficits of C57BL/6J mice in a maternal immune activation model
Sign Up to like & getrecommendations! Published in 2021 at "Neuropsychopharmacology Reports"
DOI: 10.1002/npr2.12178
Abstract: Genetic and environmental factors interact with each other to influence the risk of various psychiatric diseases; however, the intensity and nature of their interactions remain to be elucidated. We established a maternal infection model using… read more here.
Keywords: c57bl mice; inhibition; prepulse inhibition; model ... See more keywords
Abnormal [18F]NIFENE binding in transgenic 5xFAD mouse model of Alzheimer's disease: In vivo PET/CT imaging studies of α4β2* nicotinic acetylcholinergic receptors and in vitro correlations with Aβ plaques
Sign Up to like & getrecommendations! Published in 2023 at "Synapse"
DOI: 10.1002/syn.22265
Abstract: Since cholinergic dysfunction has been implicated in Alzheimer's disease (AD), the effects of Aβ plaques on nicotinic acetylcholine receptors (nAChRs) α4β2* subtype were studied using the transgenic 5xFAD mouse model of AD. Using the PET… read more here.
Keywords: 18f nifene; 5xfad mice; vivo pet; mice ... See more keywords
Active Induction of Experimental Autoimmune Encephalomyelitis in C57BL/6 Mice.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7571-6_26
Abstract: The protocol in this chapter presents a method to actively induce experimental autoimmune encephalomyelitis (EAE), one of the most widely used animal models to study efficacy of potential drugs for treatment of multiple sclerosis. Multiple… read more here.
Keywords: autoimmune encephalomyelitis; experimental autoimmune; c57bl mice;
Biparental care in C57BL/6J mice: effects on adolescent behavior and alcohol consumption
Sign Up to like & getrecommendations! Published in 2020 at "Psychopharmacology"
DOI: 10.1007/s00213-020-05501-3
Abstract: Rationale Social attachment plays an important role in offspring development. Different parenting experiences during lactation may shape offspring behavior and later alcohol use. Objectives We tested the hypothesis that differential rearing conditions (single mother, SM… read more here.
Keywords: alcohol consumption; adolescent behavior; alcohol; c57bl mice ... See more keywords
Species-specific sensitivity to intracerebroventricular streptozotocin in rats and mice highlights pathways and proteins relevant to Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Neural Transmission"
DOI: 10.1007/s00702-025-02952-w
Abstract: For over three decades, intracerebroventricular streptozotocin (STZ-icv) has been a key non-transgenic rodent model of sporadic Alzheimer’s disease. Traditionally used in rats, its use in mice is growing due to practical advantages. While factors like… read more here.
Keywords: stz icv; alzheimer disease; c57bl mice;