Complement C5a‐triggered differentiated HL‐60 stimulates migration of THP‐1 monocytic leukocytes via secretion of CCL2
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13144
Abstract: Leukocytes play an important role in vascular inflammation prior to atherosclerosis. In particular, monocyte adhesion and migration to the endothelium contribute to the development of vascular inflammation. Previously, we showed the importance of neutrophils and… read more here.
Keywords: secretion; migration thp; ccl2; complement c5a ... See more keywords
Critical role of C5a in sickle cell disease
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Hematology"
DOI: 10.1002/ajh.25384
Abstract: Innate immune complement activation may contribute to sickle cell disease (SCD) pathogenesis. Ischemia‐reperfusion physiology is a key component of the inflammatory and vaso‐occlusive milieu in SCD and is associated with complement activation. C5a is an… read more here.
Keywords: cell disease; stasis; mice; c5a ... See more keywords
Neutraligands of C5a can potentially occlude the interaction of C5a with the complement receptors C5aR1 and C5aR2
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.30360
Abstract: The complement system is central to the rapid immune response witnessed in vertebrates and invertebrates, which plays a crucial role in physiology and pathophysiology. Complement activation fuels the proteolytic cascade, which produces several complement fragments… read more here.
Keywords: c5ar1 c5ar2; c5a; complement; interaction c5a ... See more keywords
Complement C5a induces the formation of neutrophil extracellular traps by myeloid-derived suppressor cells to promote metastasis.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.12.027
Abstract: Myeloid-derived suppressor cells (MDSCs) play a major role in cancer progression. In this study, we investigated the mechanisms by which complement C5a increases the capacity of polymorphonuclear MDSCs (PMN-MDSCs) to promote tumor growth and metastatic… read more here.
Keywords: cancer; pmn mdscs; metastasis; c5a ... See more keywords
The role of human C5a as a non-genomic target in corticosteroid therapy for management of severe COVID19
Sign Up to like & getrecommendations! Published in 2021 at "Computational Biology and Chemistry"
DOI: 10.1016/j.compbiolchem.2021.107482
Abstract: Complement system plays a dual role; physiological as well as pathophysiological. While physiological role protects the host, pathophysiological role can substantially harm the host, by triggering several hyper-inflammatory pathways, referred as “hypercytokinaemia”. Emerging clinical evidence… read more here.
Keywords: management; role; c5a; severe covid19 ... See more keywords
The C5a/C5aR1 axis promotes progression of renal tubulointerstitial fibrosis in a mouse model of renal ischemia/reperfusion injury.
Sign Up to like & getrecommendations! Published in 2019 at "Kidney international"
DOI: 10.1016/j.kint.2019.01.039
Abstract: C5a is a potent proinflammatory agonist that mediates renal ischemia reperfusion (IR) injury, but the potential for modulating chronic post-ischemic fibrosis and use of therapeutic antagonist are undefined. Here we determine whether C5a receptor 1… read more here.
Keywords: renal ischemia; c5a; fibrosis; c5ar1 ... See more keywords
Effect of a C5a receptor antagonist on macrophage function in an intestinal transplant rat model.
Sign Up to like & getrecommendations! Published in 2022 at "Transplant immunology"
DOI: 10.1016/j.trim.2022.101559
Abstract: BACKGROUND C5a promotes alloreactivity via the C5a receptor 1 (C5aR1) on immune cells, but this has not been confirmed in the case of small intestine transplantation immunity. In the present study, we examined the effect… read more here.
Keywords: group; c5a receptor; macrophage; c5a ... See more keywords
Therapeutic hypothermia modulates complement factor C3a and C5a levels in a rat model of hypoxic ischemic encephalopathy
Sign Up to like & getrecommendations! Published in 2017 at "Pediatric Research"
DOI: 10.1038/pr.2016.271
Abstract: Background:Therapeutic hypothermia (HT) is the only intervention that improves outcomes in neonatal hypoxic-ischemic encephalopathy (HIE). However, the multifactorial mechanisms by which HT impacts HIE are incompletely understood. The complement system plays a major role in… read more here.
Keywords: hypoxic ischemic; therapeutic hypothermia; ischemic encephalopathy; expression ... See more keywords
Neutralizing Complement C5a Protects Mice with Pneumococcal Pulmonary Sepsis
Sign Up to like & getrecommendations! Published in 2020 at "Anesthesiology"
DOI: 10.1097/aln.0000000000003149
Abstract: Background: Community-acquired pneumonia and associated sepsis cause high mortality despite antibiotic treatment. Uncontrolled inflammatory host responses contribute to the unfavorable outcome by driving lung and extrapulmonary organ failure. The complement fragment C5a holds significant proinflammatory… read more here.
Keywords: pulmonary sepsis; sepsis; lung; c5a ... See more keywords
Clinical efficacy of complement C5a inhibition by IFX‐1 in hidradenitis suppurativa: an open‐label single‐arm trial in patients not eligible for adalimumab
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Dermatology"
DOI: 10.1111/bjd.18877
Abstract: Circulating concentrations of the split complement factor C5a are significantly increased in hidradenitis suppurativa (HS)1 . C5a exerts strong chemotaxis and activation of neutrophils at the inflammatory areas so that blockade may be a promising… read more here.
Keywords: c5a; hidradenitis suppurativa; efficacy complement; clinical efficacy ... See more keywords
C5aR1 interacts with TLR2 in osteoblasts and stimulates the osteoclast‐inducing chemokine CXCL10
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.13873
Abstract: The anaphylatoxin C5a is generated upon activation of the complement system, a crucial arm of innate immunity. C5a mediates proinflammatory actions via the C5a receptor C5aR1 and thereby promotes host defence, but also modulates tissue… read more here.
Keywords: tlr2 osteoblasts; bone; interacts tlr2; c5ar1 interacts ... See more keywords