LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "c5a" as a keyword



Complement C5a‐triggered differentiated HL‐60 stimulates migration of THP‐1 monocytic leukocytes via secretion of CCL2

Sign Up to like & get
recommendations! Published in 2021 at "FEBS Open Bio"

DOI: 10.1002/2211-5463.13144

Abstract: Leukocytes play an important role in vascular inflammation prior to atherosclerosis. In particular, monocyte adhesion and migration to the endothelium contribute to the development of vascular inflammation. Previously, we showed the importance of neutrophils and… read more here.

Keywords: secretion; migration thp; ccl2; complement c5a ... See more keywords
Photo from wikipedia

Critical role of C5a in sickle cell disease

Sign Up to like & get
recommendations! Published in 2019 at "American Journal of Hematology"

DOI: 10.1002/ajh.25384

Abstract: Innate immune complement activation may contribute to sickle cell disease (SCD) pathogenesis. Ischemia‐reperfusion physiology is a key component of the inflammatory and vaso‐occlusive milieu in SCD and is associated with complement activation. C5a is an… read more here.

Keywords: cell disease; stasis; mice; c5a ... See more keywords

Neutraligands of C5a can potentially occlude the interaction of C5a with the complement receptors C5aR1 and C5aR2

Sign Up to like & get
recommendations! Published in 2022 at "Journal of Cellular Biochemistry"

DOI: 10.1002/jcb.30360

Abstract: The complement system is central to the rapid immune response witnessed in vertebrates and invertebrates, which plays a crucial role in physiology and pathophysiology. Complement activation fuels the proteolytic cascade, which produces several complement fragments… read more here.

Keywords: c5ar1 c5ar2; c5a; complement; interaction c5a ... See more keywords

Complement C3a/C3aR and C5a/C5aR deposits accelerate the progression of advanced IgA nephropathy to end-stage renal disease

Sign Up to like & get
recommendations! Published in 2024 at "Clinical and Experimental Medicine"

DOI: 10.1007/s10238-024-01410-3

Abstract: IgA nephropathy (IgAN) is still one of the leading causes of end-stage kidney disease (ESRD), and complement system activation is a key to the pathogenesis of IgAN. The role of complement C3a/C3aR and C5a/C5aR in… read more here.

Keywords: c3a c3ar; c5a; c5ar; stage ... See more keywords

Complement C5a induces the formation of neutrophil extracellular traps by myeloid-derived suppressor cells to promote metastasis.

Sign Up to like & get
recommendations! Published in 2021 at "Cancer letters"

DOI: 10.1016/j.canlet.2021.12.027

Abstract: Myeloid-derived suppressor cells (MDSCs) play a major role in cancer progression. In this study, we investigated the mechanisms by which complement C5a increases the capacity of polymorphonuclear MDSCs (PMN-MDSCs) to promote tumor growth and metastatic… read more here.

Keywords: cancer; pmn mdscs; metastasis; c5a ... See more keywords

The role of human C5a as a non-genomic target in corticosteroid therapy for management of severe COVID19

Sign Up to like & get
recommendations! Published in 2021 at "Computational Biology and Chemistry"

DOI: 10.1016/j.compbiolchem.2021.107482

Abstract: Complement system plays a dual role; physiological as well as pathophysiological. While physiological role protects the host, pathophysiological role can substantially harm the host, by triggering several hyper-inflammatory pathways, referred as “hypercytokinaemia”. Emerging clinical evidence… read more here.

Keywords: management; role; c5a; severe covid19 ... See more keywords

The C5a/C5aR1 axis promotes progression of renal tubulointerstitial fibrosis in a mouse model of renal ischemia/reperfusion injury.

Sign Up to like & get
recommendations! Published in 2019 at "Kidney international"

DOI: 10.1016/j.kint.2019.01.039

Abstract: C5a is a potent proinflammatory agonist that mediates renal ischemia reperfusion (IR) injury, but the potential for modulating chronic post-ischemic fibrosis and use of therapeutic antagonist are undefined. Here we determine whether C5a receptor 1… read more here.

Keywords: renal ischemia; c5a; fibrosis; c5ar1 ... See more keywords

Effect of a C5a receptor antagonist on macrophage function in an intestinal transplant rat model.

Sign Up to like & get
recommendations! Published in 2022 at "Transplant immunology"

DOI: 10.1016/j.trim.2022.101559

Abstract: BACKGROUND C5a promotes alloreactivity via the C5a receptor 1 (C5aR1) on immune cells, but this has not been confirmed in the case of small intestine transplantation immunity. In the present study, we examined the effect… read more here.

Keywords: group; c5a receptor; macrophage; c5a ... See more keywords

Structure of Designer Antibody-like Peptides Binding to the Human C5a with Potential to Modulate the C5a Receptor Signaling.

Sign Up to like & get
recommendations! Published in 2024 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.4c00961

Abstract: C5a is an integral glycoprotein of the complement system that plays an important role in inflammation and immunity. The physiological concentration of C5a is observed to be elevated under various immunoinflammatory pathophysiological conditions in humans.… read more here.

Keywords: antibody like; c5a; like peptides; designer antibody ... See more keywords

Therapeutic hypothermia modulates complement factor C3a and C5a levels in a rat model of hypoxic ischemic encephalopathy

Sign Up to like & get
recommendations! Published in 2017 at "Pediatric Research"

DOI: 10.1038/pr.2016.271

Abstract: Background:Therapeutic hypothermia (HT) is the only intervention that improves outcomes in neonatal hypoxic-ischemic encephalopathy (HIE). However, the multifactorial mechanisms by which HT impacts HIE are incompletely understood. The complement system plays a major role in… read more here.

Keywords: hypoxic ischemic; therapeutic hypothermia; ischemic encephalopathy; expression ... See more keywords

85. Improved Survival with Dual Immunomodulator Treatment of ARDS by blocking C5a and IL-6 Activity: Subanalysis from the PANAMO Study in Critically Ill COVID-19 Patients

Sign Up to like & get
recommendations! Published in 2025 at "Open Forum Infectious Diseases"

DOI: 10.1093/ofid/ofae631.022

Abstract: Abstract Background Various pre-clinical and clinical studies suggest an interplay between complement C5a/C5a receptor (R1) and interleukin 6 (IL-6) signaling. C5a boosts IL-6 levels and IL-6 increases C5aR1 in inflammation and sepsis models (Fig 1).… read more here.

Keywords: inflarx gmbh; c5a; advisor consultant; consultant ... See more keywords