Group A Streptococcus Cell Wall Oligosaccharide-Streptococcal C5a Peptidase Conjugates as Effective Antibacterial Vaccines.
Sign Up to like & getrecommendations! Published in 2019 at "ACS infectious diseases"
DOI: 10.1021/acsinfecdis.9b00347
Abstract: Group A streptococcus (GAS) is one of the common Gram-positive pathogenic bacteria accounting for a variety of infectious diseases. Currently, there is no commercial vaccine for GAS. To develop efficient GAS vaccines, synthetic tri-, hexa-,… read more here.
Keywords: streptococcal c5a; c5a peptidase; group streptococcus; group ... See more keywords
Mutagenesis and immunological evaluation of group A streptococcal C5a peptidase as an antigen for vaccine development and as a carrier protein for glycoconjugate vaccine design
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DOI: 10.1039/c7ra07923k
Abstract: A truncated form (AA32-1032) of group A streptococcus (GAS) C5a peptidase (ScpA), an important GAS virulence factor, and its mutants were prepared and examined to find suitable GAS vaccine candidates and conjugate vaccine carriers. Enzymatic… read more here.
Keywords: c5a peptidase; vaccine; carrier protein; gas ... See more keywords
An activity-based probe targeting the streptococcal virulence factor C5a peptidase.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d2cc01517j
Abstract: Development of profiling strategies to provide high resolution understanding of enzymes involved in bacterial infections remains an important need. These strategies help resolve enzyme mechanisms of actions and can guide therapeutic development. We have developed… read more here.
Keywords: based probe; c5a peptidase; peptidase; activity based ... See more keywords
Multi-functional mechanisms of immune evasion by the streptococcal complement inhibitor C5a peptidase
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DOI: 10.1371/journal.ppat.1006493
Abstract: The complement cascade is crucial for clearance and control of invading pathogens, and as such is a key target for pathogen mediated host modulation. C3 is the central molecule of the complement cascade, and plays… read more here.
Keywords: c5a peptidase; complement; multi functional; c5a ... See more keywords
Immunogenicity Assessment of Different Segments and Domains of Group a Streptococcal C5a Peptidase and Their Application Potential as Carrier Protein for Glycoconjugate Vaccine Development
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DOI: 10.3390/vaccines9020139
Abstract: Group A streptococcal C5a peptidase (ScpA) is a highly conserved surface virulence factor present on group A streptococcus (GAS) cell surfaces. It has attracted much more attention as a promising antigenic target for GAS vaccine… read more here.
Keywords: streptococcal c5a; c5a peptidase; group; vaccine ... See more keywords