C5a receptor 1 promotes autoimmunity, neutrophil dysfunction and injury in experimental anti-myeloperoxidase glomerulonephritis.
Sign Up to like & getrecommendations! Published in 2018 at "Kidney international"
DOI: 10.1016/j.kint.2017.09.018
Abstract: The prospects for complement-targeted therapy in ANCA-associated vasculitis have been enhanced by a recent clinical trial in which C5a receptor 1 (C5aR1) inhibition safely replaced glucocorticoids in induction treatment. C5aR1 primes neutrophils for activation by… read more here.
Keywords: myeloperoxidase; anti myeloperoxidase; c5a receptor; inhibition ... See more keywords
Effect of a C5a receptor antagonist on macrophage function in an intestinal transplant rat model.
Sign Up to like & getrecommendations! Published in 2022 at "Transplant immunology"
DOI: 10.1016/j.trim.2022.101559
Abstract: BACKGROUND C5a promotes alloreactivity via the C5a receptor 1 (C5aR1) on immune cells, but this has not been confirmed in the case of small intestine transplantation immunity. In the present study, we examined the effect… read more here.
Keywords: group; c5a receptor; macrophage; c5a ... See more keywords
Long-term use and remission of granulomatosis with polyangiitis with the oral C5a receptor inhibitor avacopan
Sign Up to like & getrecommendations! Published in 2020 at "BMJ Case Reports"
DOI: 10.1136/bcr-2020-236236
Abstract: Granulomatosis with polyangiitis (GPA) is a rare antineutrophil cytoplasm antibody-associated vasculitis. Several therapeutic advances have occurred over the past two decades, but relapse rate remains high and refractory cases are not uncommon. Here, we present… read more here.
Keywords: receptor inhibitor; granulomatosis polyangiitis; c5a receptor;
7α-Hydroxycholesterol induces monocyte/macrophage cell expression of interleukin-8 via C5a receptor
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0173749
Abstract: We investigated effects of 7-oxygenated cholesterol derivatives present in atherosclerotic lesions, 7α-hydroxycholesterol (7αOHChol), 7β-hydroxycholesterol (7βOHChol), and 7-ketocholesterol (7K), on IL-8 expression. Transcript levels of IL-8 and secretion of its corresponding gene product by monocytes/macrophages were… read more here.
Keywords: monocyte macrophage; expression; c5a receptor; ohchol ... See more keywords
Pharmacological activation of the C5a receptor leads to stimulation of the β-adrenergic receptor and alleviates cognitive impairment in a murine model of familial Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.947071
Abstract: Alzheimer’s disease (AD) is a progressive neurodegenerative disease of the brain causing either familial or sporadic dementia. We have previously administered the modified C5a receptor agonist (EP67) for a short period to a transgenic mouse… read more here.
Keywords: alzheimer disease; cognitive impairment; c5a receptor; model ... See more keywords