LukS‐PV induces apoptosis in acute myeloid leukemia cells mediated by C5a receptor
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.2137
Abstract: LukS‐PV is one of the two components of Panton‐Valentine leucocidin (PVL). Our previous study showed that LukS‐PV can induce apoptosis in human acute myeloid leukemia (AML) THP‐1 and HL‐60 cells. C5aR (C5a receptor) is the… read more here.
Keywords: luks induce; apoptosis; receptor; c5ar ... See more keywords
Complement C3a/C3aR and C5a/C5aR deposits accelerate the progression of advanced IgA nephropathy to end-stage renal disease
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DOI: 10.1007/s10238-024-01410-3
Abstract: IgA nephropathy (IgAN) is still one of the leading causes of end-stage kidney disease (ESRD), and complement system activation is a key to the pathogenesis of IgAN. The role of complement C3a/C3aR and C5a/C5aR in… read more here.
Keywords: c3a c3ar; c5a; c5ar; stage ... See more keywords
The Novel C5aR Antagonist DF3016A Protects Neurons Against Ischemic Neuroinflammatory Injury
Sign Up to like & getrecommendations! Published in 2019 at "Neurotoxicity Research"
DOI: 10.1007/s12640-019-00026-w
Abstract: The central nervous system (CNS) constitutively expresses complement (C) membrane receptors and complement proteins, including the component C5a. This is a crucial terminal effector of the C cascade, mostly involved in pain and neuroinflammatory conditions.… read more here.
Keywords: c5ar antagonist; c5ar; novel c5ar; df3016a protects ... See more keywords
Resveratrol binding to human complement fragment 5a (hC5a) may modulate the C5aR signaling axes
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2020.1738958
Abstract: Abstract Resveratrol (RSV), the active pharmaceutical ingredient (API) found in several fruits, nuts and marketed nutraceuticals is one of the promiscuous phytoalexin known to promote good health. The health benefits of RSV could be due… read more here.
Keywords: resveratrol binding; hc5a may; hc5a; rsv ... See more keywords
Inhibition of the C5a-C5aR Axis By the L-Aptamer Aon-D21 As a New Strategy to Ameliorate Uncontrolled Migration/Motility of Hematopoietic Stem Cells - Potential Therapeutic Implications for Paroxysmal Nocturnal Hemoglobinuria
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DOI: 10.1182/blood.v130.suppl_1.1188.1188
Abstract: Background. Several mechanisms have been postulated for orchestrating the mobilization of hematopoietic stem/progenitor cells (HSPCs), and it has been proposed that activation of the complement cascade plays a crucial role in the initiation and execution… read more here.
Keywords: c5ar; aon d21; complement cascade; motility ... See more keywords
Clinicopathological features and prognostic significance of C5aR in human solid tumors: a Meta-analysis
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DOI: 10.1186/s12885-021-08883-5
Abstract: Background C5aR has been extensively studied in recent years as an essential component of the complement system. However, the role of C5aR in tumors has not been sufficiently investigated and summarized. The aim of this… read more here.
Keywords: tumor; solid tumors; c5ar; clinicopathological features ... See more keywords