C5a receptor 1 promotes autoimmunity, neutrophil dysfunction and injury in experimental anti-myeloperoxidase glomerulonephritis.
Sign Up to like & getrecommendations! Published in 2018 at "Kidney international"
DOI: 10.1016/j.kint.2017.09.018
Abstract: The prospects for complement-targeted therapy in ANCA-associated vasculitis have been enhanced by a recent clinical trial in which C5a receptor 1 (C5aR1) inhibition safely replaced glucocorticoids in induction treatment. C5aR1 primes neutrophils for activation by… read more here.
Keywords: myeloperoxidase; anti myeloperoxidase; c5a receptor; inhibition ... See more keywords
The C5a/C5aR1 axis promotes progression of renal tubulointerstitial fibrosis in a mouse model of renal ischemia/reperfusion injury.
Sign Up to like & getrecommendations! Published in 2019 at "Kidney international"
DOI: 10.1016/j.kint.2019.01.039
Abstract: C5a is a potent proinflammatory agonist that mediates renal ischemia reperfusion (IR) injury, but the potential for modulating chronic post-ischemic fibrosis and use of therapeutic antagonist are undefined. Here we determine whether C5a receptor 1… read more here.
Keywords: renal ischemia; c5a; fibrosis; c5ar1 ... See more keywords
C5aR1 Mediates the Progression of Inflammatory Responses in the Brain of Rats in the Early Stage after Ischemia and Reperfusion.
Sign Up to like & getrecommendations! Published in 2021 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.1c00244
Abstract: C5a receptor 1 (C5aR1) can induce a strong inflammatory response to an injury. Targeting C5aR1 has emerged as a novel anti-inflammatory therapeutic method. However, the role of C5aR1 in cerebral ischemia and reperfusion (I/R) injury… read more here.
Keywords: inflammatory; brain; ischemia reperfusion; injury ... See more keywords
Schwann cell C5aR1 co-opts inflammasome NLRP1 to sustain pain in a mouse model of endometriosis
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-54486-6
Abstract: Over 60% of women with endometriosis experience abdominopelvic pain and broader pain manifestations, including chronic back pain, fibromyalgia, chronic fatigue, vulvodynia, and migraine. Although the imbalance of proinflammatory mediators, including the complement component C5a, is… read more here.
Keywords: pain; schwann cells; c5ar1; schwann cell ... See more keywords
C5a–C5AR1 axis as a potential trigger of the rupture of intracranial aneurysms
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-53651-7
Abstract: Recent studies have indicated the involvement of neutrophil-mediated inflammatory responses in the process leading to intracranial aneurysm (IA) rupture. Receptors mediating neutrophil recruitment could thus be therapeutic targets of unruptured IAs. In this study, complement… read more here.
Keywords: c5a c5ar1; c5ar1; c5ar1 c5ar1; c5ar1 axis ... See more keywords
The role of C5aR1-mediated hepatic macrophage efferocytosis in NASH
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-68207-y
Abstract: Non-alcoholic fatty liver disease (NAFLD) has become the first major chronic liver disease in developed countries. 10–20% of NAFLD patients will progress to non-alcoholic steatohepatitis (NASH), and up to 25% of NASH patients may develop… read more here.
Keywords: macrophage efferocytosis; c5ar1; nash; liver ... See more keywords
C5aR1+ macrophages are involved in the progression of endometriosis
Sign Up to like & getrecommendations! Published in 2024 at "Reproductive and Developmental Medicine"
DOI: 10.1097/rd9.0000000000000120
Abstract: Objective: Immune dysfunction plays an important role in the pathogenesis of endometriosis. C5a, a by-product of complement activation, binds to its receptor (C5a receptor 1, C5aR1) in various cells, including macrophages. The combination of C5a… read more here.
Keywords: c5ar1 macrophages; endometriosis c5ar1; c5ar1; endometriosis ... See more keywords
C5aR1 interacts with TLR2 in osteoblasts and stimulates the osteoclast‐inducing chemokine CXCL10
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.13873
Abstract: The anaphylatoxin C5a is generated upon activation of the complement system, a crucial arm of innate immunity. C5a mediates proinflammatory actions via the C5a receptor C5aR1 and thereby promotes host defence, but also modulates tissue… read more here.
Keywords: tlr2 osteoblasts; bone; interacts tlr2; c5ar1 interacts ... See more keywords
Ras-Related Protein Rab5a Regulates Complement C5a Receptor Trafficking, Chemotaxis, and Chemokine Secretion in Human Macrophages
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Innate Immunity"
DOI: 10.1159/000530012
Abstract: Abstract Complement activation and Rab GTPase trafficking are commonly observed in inflammatory responses. Recruitment of innate immune cells to sites of infection or injury and secretion of inflammatory chemokines are promoted by complement component 5a… read more here.
Keywords: c5ar1; rab5a; c5a; inflammatory chemokines ... See more keywords
FBXO11 governs macrophage cell death and inflammation in response to bacterial toxins
Sign Up to like & getrecommendations! Published in 2023 at "Life Science Alliance"
DOI: 10.26508/lsa.202201735
Abstract: FBXO11 regulates the expression of the complement receptor C5aR1 and the inflammatory cytokine IL-1β, affecting how macrophages respond to Staphylococcus aureus pore–forming toxins. Staphylococcus aureus causes severe infections such as pneumonia and sepsis depending on… read more here.
Keywords: c5ar1; inflammation; fbxo11; expression ... See more keywords
The C5a/C5aR1 Axis Contributes to the Pathogenesis of Acute Cystitis Through Enhancement of Adhesion and Colonization of Uropathogenic E. coli
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2022.824505
Abstract: Our previous work using a murine model of pyelonephritis demonstrated that the C5a/C5aR1 axis plays a pathogenic role in acute kidney infection. In this study, we report that the C5a/C5aR1 axis also plays a pathogenic… read more here.
Keywords: c5ar1; bladder; infection; c5ar1 axis ... See more keywords