RGC-32' dual role in smooth muscle cells and atherogenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Clinical immunology"
DOI: 10.1016/j.clim.2022.109020
Abstract: Proliferation of endothelial cells (EC) and smooth muscle cells (SMC) is a critical process in atherosclerosis. Here, we investigated the involvement of sublytic C5b-9 effector Response Gene to Complement 32 (RGC-32) in cell cycle activation,… read more here.
Keywords: rgc; cell cycle; c5b; cycle activation ... See more keywords
C5b-9 membrane attack complex activated NLRP3 inflammasome mediates renal tubular immune injury in trichloroethylene sensitized mice.
Sign Up to like & getrecommendations! Published in 2020 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2020.111439
Abstract: Trichloroethylene (TCE) induced occupational medicamentosa-like dermatitis (OMLDT) in patients is accompanied, typically, by renal damage. But the role of C5b-9 and IL-1β in TCE-sensitized mouse renal tubular damage is unclear. This study aimed to investigate… read more here.
Keywords: renal tubular; damage; tubular epithelial; nlrp3 inflammasome ... See more keywords
#887 Complement biomarkers in IgA nephropathy and IgA vasculitis with renal involvement: can urine rather than blood be the answer?
Sign Up to like & getrecommendations! Published in 2024 at "Nephrology Dialysis Transplantation"
DOI: 10.1093/ndt/gfae069.1241
Abstract: IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide. Dysregulation of the complement system is considered a part of the pathogenesis and can occur both in the circulation and locally in the kidney. Despite this,… read more here.
Keywords: iga vasculitis; c5b; vasculitis renal; iga nephropathy ... See more keywords
Coexistence of TDP-43 and C5b-9 staining of muscle in a patient with inclusion body myositis
Sign Up to like & getrecommendations! Published in 2021 at "BMJ Case Reports"
DOI: 10.1136/bcr-2020-238312
Abstract: While sporadic inclusion body myositis (sIBM) is the most commonly acquired inflammatory myopathy above 50 years of age, its refractory response to conventional immunosuppressive treatments raises questions about its perplexing pathogenesis. Muscle biopsy typically reveals… read more here.
Keywords: body myositis; muscle; inclusion body; c5b ... See more keywords
Advances in Research on the Release of von Willebrand Factor from Endothelial Cells through the Membrane Attack Complex C5b-9 in Sepsis
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Inflammation Research"
DOI: 10.2147/jir.s520726
Abstract: Abstract Sepsis, a lethal organ dysfunction syndrome driven by aberrant host responses to infection, intertwines excessive inflammatory responses and dysregulated coagulation processes in its pathophysiology. Emerging research reveals the complement terminal membrane attack complex C5b-9… read more here.
Keywords: willebrand factor; c5b; research; sepsis ... See more keywords
Increased Serum Terminal Complements Complex Levels in Attention Deficit Hyperactivity Disorder Children
Sign Up to like & getrecommendations! Published in 2024 at "Iranian Journal of Medical Sciences"
DOI: 10.30476/ijms.2023.97556.2934
Abstract: Background: Attention deficit hyperactivity disorder (ADHD) is a widespread neuropsychiatric disorder in both children and adolescents, which is associated with social isolation and poor academic performance. Complement proteins are regarded as a major player in… read more here.
Keywords: disorder; disorder children; c5b; attention deficit ... See more keywords
C5b-9 Membrane Attack Complex Formation and Extracellular Vesicle Shedding in Barrett’s Esophagus and Esophageal Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.842023
Abstract: The early complement components have emerged as mediators of pro-oncogenic inflammation, classically inferred to cause terminal complement activation, but there are limited data on the activity of terminal complement in cancer. We previously reported elevated… read more here.
Keywords: terminal complement; c5b; complement; eac ... See more keywords
Membrane Attack Complex C5b-9 Promotes Renal Tubular Epithelial Cell Pyroptosis in Trichloroethylene-Sensitized Mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.877988
Abstract: Trichloroethylene (TCE), a commonly used organic solvent, is known to cause trichloroethylene hypersensitivity syndrome (THS), also called occupational medicamentosa–like dermatitis due to TCE (OMDT) in China. OMDT patients presented with severe inflammatory kidney damage, and… read more here.
Keywords: trichloroethylene; tce; damage; c5b ... See more keywords
Decay-Accelerating Factor Differentially Associates With Complement-Mediated Damage in Synovium After Meniscus Tear as Compared to Anterior Cruciate Ligament Injury
Sign Up to like & getrecommendations! Published in 2024 at "Immune Network"
DOI: 10.4110/in.2024.24.e17
Abstract: We have reported that anterior cruciate ligament (ACL) injury leads to the differential dysregulation of the complement system in the synovium as compared to meniscus tear (MT) and proposed this as a mechanism for a… read more here.
Keywords: anterior cruciate; acl injury; cruciate ligament; c5b ... See more keywords