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Distinct Binding Dynamics, Sites and Interactions of Fullerene and Fullerenols with Amyloid-β Peptides Revealed by Molecular Dynamics Simulations

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Published in 2019 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms20082048

Abstract: The pathology Alzheimer’s disease (AD) is associated with the self-assembly of amyloid-β (Aβ) peptides into β-sheet enriched fibrillar aggregates. A promising treatment strategy is focused on the inhibition of amyloid fibrillization of Aβ peptide. Fullerene… read more here.

Keywords: c60 c60; binding dynamics; molecular dynamics; amyloid peptides ... See more keywords