Methylenetetrahydrofolate reductase C677T polymorphism, hypertension and risk of stroke: a prospective, nested case-control study
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DOI: 10.1080/00207454.2016.1183126
Abstract: Background: Hyperhomocysteinemia is a risk factor for cardiovascular disease. To date, limited prospective studies have examined the joint effects of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, hyperhomocysteinemia and conventional vascular risk factors on risk of… read more here.
Keywords: risk; c677t; c677t polymorphism; risk stroke ... See more keywords
MTHFR C677T gene polymorphism and the severity of coronary lesions in acute coronary syndrome
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DOI: 10.1097/md.0000000000009044
Abstract: Abstract The association between methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, circulating levels of homocysteine (Hcy), and the severity of coronary lesion in patients with acute coronary syndrome (ACS) remains unknown. Consecutive ACS patients were included. MTHFR… read more here.
Keywords: coronary lesions; c677t; mthfr c677t; severity coronary ... See more keywords
Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and male infertility risk
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DOI: 10.1097/md.0000000000023662
Abstract: Supplemental Digital Content is available in the text Abstract Background: 18 previous meta-analyses have been published on the methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms with male infertility risk. However, results of the previous meta-analyses… read more here.
Keywords: infertility risk; male infertility; bfdp; c677t ... See more keywords
Involvement of C677T MTHFR variant but not A1298C in methotrexate-induced toxicity in acute lymphoblastic leukemia
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DOI: 10.1177/1078155220951898
Abstract: Background Methotrexate (MTX) is a key drug in acute lymphoblastic leukemia (ALL) treatment; it inhibits DNA replication by blocking the conversion of 5, 10 Methylenetetrahydrofolate to 5-methylene tetrahydrofolate by methylenetetrahydrofolate reductase (MTHFR). Variants of the… read more here.
Keywords: methotrexate; c677t; lymphoblastic leukemia; toxicity ... See more keywords
Frequency of three prothrombotic polymorphisms among Syrian population: factor V G1691A, prothrombin G20210A and methylenetetrahydrofolate reductase C677T
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DOI: 10.3109/03014460.2015.1119308
Abstract: Abstract Background: Thrombophilia is a multi-factorial disorder caused by inherited and acquired factors. Among the inherited factors are factor V G1691A, prothrombin G20210A and methylenetetrahydrofolate reductase (MTHFR) C677T single nucleotide polymorphisms (SNPs). Aim: The main… read more here.
Keywords: c677t; prothrombin g20210a; g1691a prothrombin; syrian population ... See more keywords
Roles of 5,10-Methylenetetrahydrofolate Reductase C677T Polymorphisms in First-Episode, Drug-Naive Adult Patients With Depression
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DOI: 10.3389/fpsyt.2020.531959
Abstract: 5,10-Methylenetetrahydrofolate reductase (MTHFR) gene C677T polymorphism is considered as a predisposition and promising genetic candidate to major depressive disorder (MDD), as it is associated with impaired one-carbon cycles, which may be involved in the pathogenesis… read more here.
Keywords: depression; methylenetetrahydrofolate reductase; c677t; first episode ... See more keywords
Methylenetetrahydrofolate Reductase C677T Gene Variant in Relation to Body Mass Index and Folate Concentration in a Polish Population
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DOI: 10.3390/biomedicines10123140
Abstract: Background: Methylenetetrahydrofolate reductase (MTHFR) is an enzyme responsible for producing an active form of folate. The MTHFR T677T genotype may have adverse health effects associated with weight gain and a reduction in folate availability. Aim:… read more here.
Keywords: methylenetetrahydrofolate reductase; genotype; body mass; folate ... See more keywords
Methylenetetrahydrofolate reductase C677T polymorphism and toxicity to 5-FU-based chemotherapy in colorectal cancer
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DOI: 10.4314/tjpr.v19i1.30
Abstract: Purpose: To investigate the toxicity of methylenetetrahydrofolate reductase (MTHFR) polymorphism in colorectal cancer patients treated with 5-fluorouracil (5-FU).Methods: A total of 105 patients with colorectal cancer who underwent 5-FU therapy were included in this study.… read more here.
Keywords: mthfr c677t; c677t; toxicity; polymorphism ... See more keywords