Directional Breathing of Fullerene Cages: Crystallographic Evidence for Endohedral C2-Triggered Elongation of Cs(6)-C82 Cage.
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DOI: 10.1021/acs.inorgchem.5c02622
Abstract: The interplay between fullerene cages and endohedral units is crucial for the stability and properties of endohedral metallofullerenes (EMFs). However, clear visualization of such an interplay remains rare due to the scarcity of suitable comparative… read more here.
Keywords: c82 cage; c82; fullerene cages; cage ... See more keywords
Isolation and Structural Characterization of Er@ C2 v(9)-C82 and Er@ C s(6)-C82: Regioselective Dimerization of a Pristine Endohedral Metallofullerene Induced by Cage Symmetry.
Sign Up to like & getrecommendations! Published in 2019 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.8b03313
Abstract: Two Er@C82 isomers have been isolated and unambiguously characterized as Er@ C2 v(9)-C82 and Er@ C s(6)-C82, respectively, by single-crystal X-ray diffraction. Er@ C s(6)-C82 is identified as a dimeric structure in the crystalline state,… read more here.
Keywords: c82 c82; dimerization; regioselective dimerization; c82 ... See more keywords
Positron Emission Tomography/Magnetic Resonance Imaging of Glioblastoma Using a Functionalized Gadofullerene Nanoparticle.
Sign Up to like & getrecommendations! Published in 2019 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.9b03542
Abstract: Water-soluble gadofullerene nanomaterials have been extensively investigated as magnetic resonance imaging (MRI) contrast agents, radical scavengers, sensitizers for photodynamic therapy, and inherent antineoplastic agents. Most recently, an alanine-modified gadofullerene nanoparticle (Gd@C82-Ala) with excellent anticancer activity… read more here.
Keywords: resonance imaging; glioblastoma; magnetic resonance; c82 ... See more keywords
ThCTi@Cs(6)-C82: Th═C Double Bond in a Mixed Actinide-Transition Metal Cluster.
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DOI: 10.1021/jacs.4c15253
Abstract: A thorium-carbon double bond that corresponds to the sum of theoretical covalent double bond radii has long been sought after in the study of actinide-ligand multiple bonding as a synthetic target. However, the stabilization of… read more here.
Keywords: actinide transition; c82; cluster; double bond ... See more keywords
Charging nanoparticles: increased binding of Gd@C82(OH)22 derivatives to human MMP-9.
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DOI: 10.1039/c8nr00127h
Abstract: Unlike most matrix metalloproteinase (MMP) inhibitors, which target the conserved catalytic zinc site, Gd@C82(OH)22 indirectly inhibits MMP-9 activity by binding at the ligand specificity S1' loop. The allosteric binding makes Gd@C82(OH)22 a promising inhibitor selective… read more here.
Keywords: c82 derivatives; group; mmp; human mmp ... See more keywords
Gd-Metallofullerenol nanoparticles cause intracellular accumulation of PDGFR-α and morphology alteration of fibroblasts.
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DOI: 10.1039/c8nr08667b
Abstract: Gadolinium-metallofullerenols (Gd@C82(OH)22) are a promising agent for cancer therapy and have shown beneficial effects in regulating the tumor microenvironment with low toxicity. However, the underlying mechanism by which Gd@C82(OH)22 interacts with fibroblasts remains unclear. In… read more here.
Keywords: accumulation; metallofullerenol nanoparticles; morphology; c82 ... See more keywords
The Molecular Mechanism of Human Voltage-Dependent Anion Channel 1 Blockade by the Metallofullerenol Gd@C82(OH)22: An In Silico Study
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DOI: 10.3390/biom12010123
Abstract: The endohedral metallofullerenol Gd@C82(OH)22 has been identified as a possible antineoplastic agent that can inhibit both the growth and metastasis of cancer cells. Despite these potentially important effects, our understanding of the interactions between Gd@C82(OH)22… read more here.
Keywords: human voltage; anion channel; c82; dependent anion ... See more keywords
A Novel Drug Design Strategy: An Inspiration from Encaging Tumor by Metallofullerenol Gd@C82(OH)22
Sign Up to like & getrecommendations! Published in 2019 at "Molecules"
DOI: 10.3390/molecules24132387
Abstract: Cancer remains a major threat to human health worldwide. Cytotoxicity has imposed restrictions on the conventional cytotoxic drug-based chemotherapy. The rapidly-developing nanomedicine has shown great promise in revolutionizing chemotherapy with improved efficiency and reduced toxicity.… read more here.
Keywords: drug design; drug; c82; metallofullerenol ... See more keywords