Isolation and Structural Characterization of Er@ C2 v(9)-C82 and Er@ C s(6)-C82: Regioselective Dimerization of a Pristine Endohedral Metallofullerene Induced by Cage Symmetry.
Sign Up to like & getrecommendations! Published in 2019 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.8b03313
Abstract: Two Er@C82 isomers have been isolated and unambiguously characterized as Er@ C2 v(9)-C82 and Er@ C s(6)-C82, respectively, by single-crystal X-ray diffraction. Er@ C s(6)-C82 is identified as a dimeric structure in the crystalline state,… read more here.
Keywords: c82 c82; dimerization; regioselective dimerization; c82 ... See more keywords
Positron Emission Tomography/Magnetic Resonance Imaging of Glioblastoma Using a Functionalized Gadofullerene Nanoparticle.
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DOI: 10.1021/acsami.9b03542
Abstract: Water-soluble gadofullerene nanomaterials have been extensively investigated as magnetic resonance imaging (MRI) contrast agents, radical scavengers, sensitizers for photodynamic therapy, and inherent antineoplastic agents. Most recently, an alanine-modified gadofullerene nanoparticle (Gd@C82-Ala) with excellent anticancer activity… read more here.
Keywords: resonance imaging; glioblastoma; magnetic resonance; c82 ... See more keywords
Charging nanoparticles: increased binding of Gd@C82(OH)22 derivatives to human MMP-9.
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DOI: 10.1039/c8nr00127h
Abstract: Unlike most matrix metalloproteinase (MMP) inhibitors, which target the conserved catalytic zinc site, Gd@C82(OH)22 indirectly inhibits MMP-9 activity by binding at the ligand specificity S1' loop. The allosteric binding makes Gd@C82(OH)22 a promising inhibitor selective… read more here.
Keywords: c82 derivatives; group; mmp; human mmp ... See more keywords
Gd-Metallofullerenol nanoparticles cause intracellular accumulation of PDGFR-α and morphology alteration of fibroblasts.
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DOI: 10.1039/c8nr08667b
Abstract: Gadolinium-metallofullerenols (Gd@C82(OH)22) are a promising agent for cancer therapy and have shown beneficial effects in regulating the tumor microenvironment with low toxicity. However, the underlying mechanism by which Gd@C82(OH)22 interacts with fibroblasts remains unclear. In… read more here.
Keywords: accumulation; metallofullerenol nanoparticles; morphology; c82 ... See more keywords
The Molecular Mechanism of Human Voltage-Dependent Anion Channel 1 Blockade by the Metallofullerenol Gd@C82(OH)22: An In Silico Study
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DOI: 10.3390/biom12010123
Abstract: The endohedral metallofullerenol Gd@C82(OH)22 has been identified as a possible antineoplastic agent that can inhibit both the growth and metastasis of cancer cells. Despite these potentially important effects, our understanding of the interactions between Gd@C82(OH)22… read more here.
Keywords: human voltage; anion channel; c82; dependent anion ... See more keywords
A Novel Drug Design Strategy: An Inspiration from Encaging Tumor by Metallofullerenol Gd@C82(OH)22
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DOI: 10.3390/molecules24132387
Abstract: Cancer remains a major threat to human health worldwide. Cytotoxicity has imposed restrictions on the conventional cytotoxic drug-based chemotherapy. The rapidly-developing nanomedicine has shown great promise in revolutionizing chemotherapy with improved efficiency and reduced toxicity.… read more here.
Keywords: drug design; drug; c82; metallofullerenol ... See more keywords