Charging nanoparticles: increased binding of Gd@C82(OH)22 derivatives to human MMP-9.
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DOI: 10.1039/c8nr00127h
Abstract: Unlike most matrix metalloproteinase (MMP) inhibitors, which target the conserved catalytic zinc site, Gd@C82(OH)22 indirectly inhibits MMP-9 activity by binding at the ligand specificity S1' loop. The allosteric binding makes Gd@C82(OH)22 a promising inhibitor selective… read more here.
Keywords: c82 derivatives; group; mmp; human mmp ... See more keywords