Selenoprotein S is required for clearance of C99 through endoplasmic reticulum-associated degradation.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.03.060
Abstract: Amyloid beta precursor protein (APP) is normally cleaved by α-secretase, but can also be cleaved by β-secretase (BACE1) to produce C99 fragments in the endoplasmic reticulum (ER) membrane. C99 is subsequently cleaved to amyloid β… read more here.
Keywords: degradation; endoplasmic reticulum; reticulum associated; c99 ... See more keywords
Does Intraneuronal Accumulation of Carboxyl-terminal Fragments of the Amyloid Precursor Protein Trigger Early Neurotoxicity in Alzheimer's Disease?
Sign Up to like & getrecommendations! Published in 2019 at "Current Alzheimer research"
DOI: 10.2174/1567205016666190325092841
Abstract: BACKGROUND Alzheimer's disease (AD) is associated with extracellular accumulation and aggregation of amyloid β (Aβ) peptides ultimately seeding in senile plaques. Recent data show that their direct precursor C99 (βCTF) also accumulates in AD-affected brain… read more here.
Keywords: accumulation; alzheimer disease; pathology; alzheimer ... See more keywords
Effect of Cholesterol on C99 Dimerization: Revealed by Molecular Dynamics Simulations
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2022.872385
Abstract: C99 is the immediate precursor for amyloid beta (Aβ) and therefore is a central intermediate in the pathway that is believed to result in Alzheimer’s disease (AD). It has been suggested that cholesterol is associated… read more here.
Keywords: dynamics simulations; c99; molecular dynamics; c99 dimerization ... See more keywords