Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS
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DOI: 10.1016/j.ebiom.2018.11.067
Abstract: Background Astrocytes regulate neuronal function, synaptic formation and maintenance partly through secreted extracellular vesicles (EVs). In amyotrophic lateral sclerosis (ALS) astrocytes display a toxic phenotype that contributes to motor neuron (MN) degeneration. Methods We used… read more here.
Keywords: extracellular vesicles; mir 494; network; astrocyte derived ... See more keywords
Physical exercise is a risk factor for amyotrophic lateral sclerosis: Convergent evidence from Mendelian randomisation, transcriptomics and risk genotypes
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DOI: 10.1016/j.ebiom.2021.103397
Abstract: Background Amyotrophic lateral sclerosis (ALS) is a universally fatal neurodegenerative disease. ALS is determined by gene-environment interactions and improved understanding of these interactions may lead to effective personalised medicine. The role of physical exercise in… read more here.
Keywords: evidence; amyotrophic lateral; exercise; physical exercise ... See more keywords
Cell-autonomous immune dysfunction driven by disrupted autophagy in C9orf72-ALS iPSC-derived microglia contributes to neurodegeneration
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DOI: 10.1126/sciadv.abq0651
Abstract: The most common genetic mutation found in familial and sporadic amyotrophic lateral sclerosis (ALS), as well as fronto-temporal dementia (FTD), is a repeat expansion in the C9orf72 gene. C9orf72 is highly expressed in human myeloid… read more here.
Keywords: derived microglia; disrupted autophagy; cell autonomous; c9orf72 als ... See more keywords