C9orf72 arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import
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DOI: 10.7554/elife.51685
Abstract: Disruption of nucleocytoplasmic transport is increasingly implicated in the pathogenesis of neurodegenerative diseases, including ALS caused by a C9orf72 hexanucleotide repeat expansion. However, the mechanism(s) remain unclear. Karyopherins, including importin β and its cargo adaptors,… read more here.
Keywords: repeat proteins; c9orf72 arginine; repeat; arginine ... See more keywords