C9orf72 loss-of-function: a trivial, stand-alone or additive mechanism in C9 ALS/FTD?
Sign Up to like & getrecommendations! Published in 2020 at "Acta Neuropathologica"
DOI: 10.1007/s00401-020-02214-x
Abstract: A repeat expansion in C9orf72 is responsible for the characteristic neurodegeneration in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) in a still unresolved manner. Proposed mechanisms involve gain-of-functions, comprising RNA and protein toxicity, and… read more here.
Keywords: function; als ftd; c9orf72 loss; loss function ... See more keywords