CA1 pyramidal neuron gene expression mosaics in the Ts65Dn murine model of Down syndrome and Alzheimer's disease following maternal choline supplementation
Sign Up to like & getrecommendations! Published in 2018 at "Hippocampus"
DOI: 10.1002/hipo.22832
Abstract: Although there are changes in gene expression and alterations in neuronal density and afferent inputs in the forebrain of trisomic mouse models of Down syndrome (DS) and Alzheimer's disease (AD), there is a lack of… read more here.
Keywords: alzheimer disease; ca1 pyramidal; gene expression; syndrome alzheimer ... See more keywords
Interplay between global and pathway-specific synaptic plasticity in CA1 pyramidal cells
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-17161-z
Abstract: Mechanisms underlying information storage have been depicted for global cell-wide and pathway-specific synaptic plasticity. Yet, little is known how these forms of plasticity interact to enhance synaptic competition and network stability. We examined synaptic interactions… read more here.
Keywords: pathway specific; ca1 pyramidal; specific synaptic; pathway ... See more keywords
Down-regulation of cyclin-dependent kinase 5 attenuates p53-dependent apoptosis of hippocampal CA1 pyramidal neurons following transient cerebral ischemia
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-49623-x
Abstract: Abnormal activation of cyclin-dependent kinase 5 (Cdk5) is associated with pathophysiological conditions. Ischemic preconditioning (IPC) can provide neuroprotective effects against subsequent lethal ischemic insult. The objective of this study was to determine how Cdk5 and… read more here.
Keywords: ipc; cyclin dependent; ca1 pyramidal; pyramidal neurons ... See more keywords
The possible consequences for cognitive functions of external electric fields at power line frequency on hippocampal CA1 pyramidal neurons
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Neuroscience"
DOI: 10.1111/ejn.13325
Abstract: The possible effects on cognitive processes of external electric fields, such as those generated by power line pillars and household appliances are of increasing public concern. They are difficult to study experimentally, and the relatively… read more here.
Keywords: external electric; electric fields; power line; ca1 pyramidal ... See more keywords
Spared CA1 pyramidal neuron function and hippocampal performance following antisense knockdown of microRNA‐134
Sign Up to like & getrecommendations! Published in 2018 at "Epilepsia"
DOI: 10.1111/epi.14475
Abstract: Inhibition of microRNA‐134 by an oligonucleotide antagomir (ant‐134) has been shown to produce powerful antiseizure effects in multiple models of epilepsy. However, to successfully translate the treatment to the clinic, it is important to assess… read more here.
Keywords: microrna 134; spared ca1; ca1 pyramidal; function hippocampal ... See more keywords
-Most hippocampal CA1 pyramidal cells in rabbits increase firing during awake sharp-wave ripples and some do so in response to external stimulation and theta.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of neurophysiology"
DOI: 10.1152/jn.00056.2020
Abstract: Hippocampus forms neural representations of real-life events including multimodal information of spatial and temporal context. These representations, i.e. organized sequences of neuronal firing are repeated during following rest and sleep, especially when so-called sharp-wave ripples… read more here.
Keywords: ca1 pyramidal; theta; response; pyramidal cells ... See more keywords
Synaptic Integration in CA1 Pyramidal Neurons Is Intact despite Deficits in GABAergic Transmission in the Scn1a Haploinsufficiency Mouse Model of Dravet Syndrome
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DOI: 10.1523/eneuro.0080-22.2022
Abstract: Abstract Mutations of SCN1A, which encodes the voltage-gated sodium channel Nav1.1, can cause epilepsy disorders such as Dravet syndrome (DS) that are comorbid with wide-ranging neurologic dysfunction. Many studies suggest that Nav1.1 haploinsufficiency causes forebrain… read more here.
Keywords: pyramidal neurons; ca1 pyramidal; synaptic integration; physiology ... See more keywords
Forebrain Glucocorticoid Receptor Overexpression Alters Behavioral Encoding of Hippocampal CA1 Pyramidal Cells in Mice
Sign Up to like & getrecommendations! Published in 2022 at "eNeuro"
DOI: 10.1523/eneuro.0126-22.2022
Abstract: Abstract Glucocorticoid signaling influences hippocampal-dependent behavior and vulnerability to stress-related neuropsychiatric disorders. In mice, lifelong overexpression of glucocorticoid receptor (GR) in forebrain excitatory neurons altered exploratory behavior, cognition, and dorsal hippocampal gene expression in adulthood,… read more here.
Keywords: ca1; glucocorticoid receptor; overexpression; ca1 pyramidal ... See more keywords
Recurring Cholinergic Inputs Induce Local Hippocampal Plasticity through Feedforward Disinhibition
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DOI: 10.1523/eneuro.0389-21.2022
Abstract: Abstract The CA1 pyramidal neurons are embedded in an intricate local circuitry that contains a variety of interneurons. The roles these interneurons play in the regulation of the excitatory synaptic plasticity remains largely understudied. Recent… read more here.
Keywords: pyramidal neurons; disinhibition; hippocampal plasticity; recurring cholinergic ... See more keywords
Persistent Firing in Hippocampal CA1 Pyramidal Cells in Young and Aged Rats
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DOI: 10.1523/eneuro.0479-22.2023
Abstract: Abstract Persistent neuronal firing is often observed in working memory and temporal association tasks both in humans and animals, and is believed to retain necessary information in these tasks. We have reported that hippocampal CA1… read more here.
Keywords: aged rats; ca1 pyramidal; hippocampal ca1; persistent firing ... See more keywords
Analysis of Age-Dependent Alterations in Excitability Properties of CA1 Pyramidal Neurons in an APPPS1 Model of Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2021.668948
Abstract: Age-dependent accumulation of amyloid-β, provoking increasing brain amyloidopathy, triggers abnormal patterns of neuron activity and circuit synchronization in Alzheimer’s disease (AD) as observed in human AD patients and AD mouse models. Recent studies on AD… read more here.
Keywords: age dependent; analysis; ca1 pyramidal; disease ... See more keywords