Orexin receptors in the CA1 region of hippocampus modulate the stress-induced antinociceptive responses in an animal model of persistent inflammatory pain
Sign Up to like & getrecommendations! Published in 2022 at "Peptides"
DOI: 10.1016/j.peptides.2021.170679
Abstract: Stress activates multiple neural pathways and neurotransmitters that often suppress pain perception, the phenomenon called stress-induced analgesia (SIA). Orexin neurons from the lateral hypothalamus project to entire brain structures such as the hippocampus. The present… read more here.
Keywords: region hippocampus; ca1 region; stress induced; formalin test ... See more keywords
Bioinformatics Data Analysis of Hippocampal CA1 Region in Alzheimer’s Disease Reversing GSEA Using Construction of Protein Interaction Network of Key Genes
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Biomedical Nanotechnology"
DOI: 10.1166/jbn.2023.3530
Abstract: We aimed to conduct bioinformatics analysis of genes differentially expressed in the cornu ammonis (CA1) region of the hippocampus of Alzheimer’s disease (AD) at differents tages and to explore AD and Molecular mechanisms of occurrence.… read more here.
Keywords: network; protein interaction; key genes; alzheimer disease ... See more keywords
Intraarterial anti-leptin therapy via ICA protects ipsilateral CA1 neurons subjected to ischemia and reperfusion
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0261644
Abstract: Background Brain reperfusion following an ischemic event is essential for tissue viability, however, it also involves processes that promote neuronal cell death. We have recently shown that local expression of the hormone leptin in cardiovascular… read more here.
Keywords: ca1 neurons; leptin; reperfusion; leptin antagonist ... See more keywords
Activation of astrocyte Gq pathway in hippocampal CA1 region attenuates anesthesia/surgery induced cognitive dysfunction in aged mice
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.1040569
Abstract: The elderly are particularly vulnerable to brain dysfunction after fracture surgery, but the mechanism underlying the cognitive decline due to anesthesia/surgery is not well understood. In this study, we observed hippocampus-dependent cognitive impairment in aged… read more here.
Keywords: cognitive dysfunction; surgery; dysfunction aged; aged mice ... See more keywords
Activating Interneurons in Local Inhibitory Circuits by High-Frequency Stimulations at the Efferent Fibers of Pyramidal Neurons in Rat Hippocampal CA1 Region
Sign Up to like & getrecommendations! Published in 2022 at "Brain Sciences"
DOI: 10.3390/brainsci12101350
Abstract: Stimulation-induced inhibition is one of the important effects of high-frequency stimulation (HFS) utilized by the therapy of deep brain stimulation (DBS) to treat certain neurological diseases such as epilepsy. In order to explore the stimulation… read more here.
Keywords: pyramidal neurons; local inhibitory; efferent fibers; hfs ... See more keywords
Less hippocampal neuronal death in young gerbils following transient global cerebral ischemia is associated with long-term maintenance of insulin-like growth factor 1 and its receptors in the hippocampal CA1 region
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2017.8243
Abstract: Insulin-like growth factor 1 (IGF-1) is a well-known growth factor with well-defined neuroprotective effects against cerebral ischemia. However, the age-dependent differences in the expression of IGF-1 and its receptor (IGF-1R) in the brain following transient… read more here.
Keywords: adult; ca1 region; cerebral ischemia; growth factor ... See more keywords
Activation of metabotropic glutamate receptor 1 regulates hippocampal CA1 region excitability in rats with status epilepticus by suppressing the HCN1 channel
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.350206
Abstract: Dysregulation of hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channels alters neuronal excitability. However, the role of HCN channels in status epilepticus is not fully understood. In this study, we established rat models of pentylenetetrazole-induced status epilepticus.… read more here.
Keywords: status epilepticus; hcn1 channel; status; expression ... See more keywords