Tumor‐shed antigen CA125 blocks complement‐mediated killing via suppression of C1q‐antibody binding
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Immunology"
DOI: 10.1002/eji.201847707
Abstract: C1q‐engagement with IgG and IgM type antibodies is the initiating step of classical complement‐mediated immunity. The tumor shed antigen CA125 has been reported to have immunosuppressive effects on host tumor responses as well as commercially… read more here.
Keywords: ca125; antibody; c1q; complement ... See more keywords
Ovarian cancer early detection by circulating CA125 in the context of anti‐CA125 autoantibody levels: Results from the EPIC cohort
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Cancer"
DOI: 10.1002/ijc.31164
Abstract: CA125 is the best ovarian cancer early detection marker to date; however, sensitivity is limited and complementary markers are required to improve discrimination between ovarian cancer cases and non‐cases. Anti‐CA125 autoantibodies are observed in circulation.… read more here.
Keywords: early detection; ca125; anti ca125; ovarian cancer ... See more keywords
Validation of tissue factor pathway inhibitor 2 as a specific biomarker for preoperative prediction of clear cell carcinoma of the ovary
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Clinical Oncology"
DOI: 10.1007/s10147-021-01914-y
Abstract: Tissue factor pathway inhibitor 2 (TFPI2) is a novel serum biomarker that discriminates ovarian clear cell carcinoma (CCC) from borderline ovarian tumors (BOTs) and non-clear cell epithelial ovarian cancers (EOCs). Here, we examined the performance… read more here.
Keywords: ccc; ca125; tfpi2; tissue factor ... See more keywords
Potential risk factors of ovarian cancer and analysis of CA125, a biomarker used for its monitoring and diagnosis
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology Reports"
DOI: 10.1007/s11033-019-04794-8
Abstract: Ovarian cancer (OC) is the fourth most common cancer among Pakistani, Scottish and Chinese women. The aim of the present study was to determine the association of potential risk factors with OC and analysis of… read more here.
Keywords: cancer; ca125; family history; age ... See more keywords
Nano-sized CA125 antigen glycocamouflage: Mucin - Extracellular vesicles alliance to watch?
Sign Up to like & getrecommendations! Published in 2018 at "Archives of biochemistry and biophysics"
DOI: 10.1016/j.abb.2018.06.017
Abstract: Mucin 16 (MUC16) is a transmembrane type mucin and its released extracellular portion is designated as CA125 antigen. It is considered to be part of a supramolecular glycoprotein complex having a complicated epitope map and… read more here.
Keywords: extracellular vesicles; ca125; nano sized; ca125 antigen ... See more keywords
Engineering a G-quadruplex-based logic gate platform for sensitive assay of dual biomarkers of ovarian cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Analytica chimica acta"
DOI: 10.1016/j.aca.2022.339559
Abstract: As most single tumor markers have low sensitivity or specificity, the joint detection of multiple tumor biomarkers is helpful to improve the positive rate and specificity of early diagnosis. To establish a sensitive, specific, and… read more here.
Keywords: gate; cea; ca125; dual biomarkers ... See more keywords
CA125 Predicts Right Heart Hemodynamic and Function and Identifies Distinct Congestion Phenotypes: Guidance for Therapy
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Heart and Lung Transplantation"
DOI: 10.1016/j.healun.2021.01.1809
Abstract: Purpose Elevated carbohydrate antigen 125 (CA125) correlates with serosal effusions and has previously been thought to be associated with the clinical severity of heart failure (HF) and fluid congestion. We assessed CA125 as a predictor… read more here.
Keywords: right heart; heart; congestion phenotypes; ca125 predicts ... See more keywords
Comparison between CA125 and NT-proBNP for evaluating congestion in acute heart failure.
Sign Up to like & getrecommendations! Published in 2020 at "Medicina clinica"
DOI: 10.1016/j.medcli.2020.05.063
Abstract: BACKGROUND Carbohydrate antigen 125 (CA125) and B-type natriuretic peptides are surrogate markers of congestion in patients with acute heart failure (AHF). The aim of the study was to assess the association between CA125 and NT-proBNP… read more here.
Keywords: ca125; heart failure; acute heart; congestion ... See more keywords
An aptamer biosensor for CA125 quantification in human serum based on upconversion luminescence resonance energy transfer
Sign Up to like & getrecommendations! Published in 2021 at "Microchemical Journal"
DOI: 10.1016/j.microc.2020.105761
Abstract: Abstract CA125 is the most widely used biomarker for the early detection of ovarian cancer. Luminescence resonance energy transfer (LRET)-based probes show pronounced specificity and simplicity for CA125 detection, but they suffer from strong interference… read more here.
Keywords: detection; energy; ca125; luminescence resonance ... See more keywords
Elevated preoperative CA125 is associated with poor survival in patients with metastatic colorectal cancer undergoing primary tumor resection: a retrospective cohort study
Sign Up to like & getrecommendations! Published in 2022 at "Gastroenterology Report"
DOI: 10.1093/gastro/goac020
Abstract: Abstract Background The impact of the preoperative carbohydrate antigen 125 (CA125) level on the survival of metastatic colorectal cancer (CRC) patients undergoing primary tumor resection (PTR) remains uncertain. The aim of this study was to… read more here.
Keywords: ca125; preoperative ca125; primary tumor; patients elevated ... See more keywords
CA125 modified by PLT and NLR improves the predictive accuracy of adenomyosis-derived pelvic dense adhesion
Sign Up to like & getrecommendations! Published in 2017 at "Medicine"
DOI: 10.1097/md.0000000000006880
Abstract: Abstract To explore the value of serum levels of CA125, platelet count (PLT), neutrophil–lymphocyte ratio (NLR), and modified CA125 markers CA125a and CA125b in predicting pelvic dense adhesion (PDA) associated with adenomyosis, CA125a = lg(CA125 × PLT × 109),… read more here.
Keywords: adenomyosis; ca125; adenomyosis derived; plt nlr ... See more keywords