Rearrangements under confinement lead to increased binding energy of Synaptotagmin‐1 with anionic membranes in Mg2+ and Ca2+
Sign Up to like & getrecommendations! Published in 2018 at "FEBS Letters"
DOI: 10.1002/1873-3468.13040
Abstract: Synaptotagmin‐1 (Syt1) is the primary calcium sensor (Ca2+) that mediates neurotransmitter release at the synapse. The tandem C2 domains (C2A and C2B) of Syt1 exhibit functionally critical, Ca2+‐dependent interactions with the plasma membrane. With the… read more here.
Keywords: synaptotagmin; rearrangements confinement; binding energy; ca2 ... See more keywords
NCS‐1 expression is higher in basal breast cancers and regulates calcium influx and cytotoxic responses to doxorubicin
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12589
Abstract: Neuronal calcium sensor‐1 (NCS‐1) is a positive modulator of IP3 receptors and was recently associated with poorer survival in breast cancers. However, the association between NCS‐1 and breast cancer molecular subtypes and the effects of… read more here.
Keywords: basal breast; breast; breast cancer; breast cancers ... See more keywords
A Calcium Fluoride Nanozyme for Ultrasound‐Amplified and Ca2+‐Overload‐Enhanced Catalytic Tumor Nanotherapy
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202205680
Abstract: The anticancer mechanism of nanozymes is dominantly associated with the capacity for generation of reactive oxygen species (ROS) caused by the valence change of metal elements. However, very little research is focused on and has… read more here.
Keywords: calcium; ca2 overload; calcium fluoride; tumor ... See more keywords
Orai1 is an Entotic Ca2+ Channel for Non‐Apoptotic Cell Death, Entosis in Cancer Development
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202205913
Abstract: Entosis is a non‐apoptotic cell death process that forms characteristic cell‐in‐cell structures in cancers, killing invading cells. Intracellular Ca2+ dynamics are essential for cellular processes, including actomyosin contractility, migration, and autophagy. However, the significance of… read more here.
Keywords: cell death; non apoptotic; apoptotic cell; entosis ... See more keywords
Effects of mitochondria‐associated Ca2+ transporters suppression on oocyte activation
Sign Up to like & getrecommendations! Published in 2020 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3571
Abstract: Oocyte activation deficiency leads to female infertility. [Ca2+]i oscillations are required for mitochondrial energy supplement transition from the resting to the excited state, but the underlying mechanisms are still very little known. Three mitochondrial Ca2+… read more here.
Keywords: associated ca2; effects mitochondria; mitochondria associated; ca2 ... See more keywords
Bufalin induces apoptosis and autophagy via the Ca2+/CaMKKβ/AMPK/Beclin1 signaling pathway in osteosarcoma cells.
Sign Up to like & getrecommendations! Published in 2023 at "Cell biology international"
DOI: 10.1002/cbin.12021
Abstract: Bufalin, a major cardiotonic compound of the traditional Chinese medicine Chanshu has been used for cancer treatment for several years. However, the molecular mechanisms of Bufalin-induced autophagy in osteosarcoma (OS) is not fully understood. In… read more here.
Keywords: ampk beclin1; apoptosis autophagy; bufalin; bufalin induced ... See more keywords
Omecamtiv mecarbil augments cardiomyocyte contractile activity both at resting and systolic Ca2+ levels
Sign Up to like & getrecommendations! Published in 2023 at "ESC Heart Failure"
DOI: 10.1002/ehf2.14300
Abstract: Heart failure with reduced ejection fraction (HFrEF) is a disease with high mortality and morbidity. Recent positive inotropic drug developments focused on cardiac myofilaments, that is, direct activators of the myosin molecule and Ca2+ sensitizers… read more here.
Keywords: omecamtiv mecarbil; cardiomyocyte contractile; mecarbil augments; augments cardiomyocyte ... See more keywords
Rebalancing protein phosphorylation in heart failure to prevent arrhythmias
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.1315
Abstract: In Europe, more than 15 million people are diagnosed with heart failure (HF), and this number continues to increase, representing a major cause of hospitalization and death. About half of the HF patient population presents… read more here.
Keywords: protein phosphorylation; heart; ca2; heart failure ... See more keywords
Dopamine elevates and lowers astroglial Ca2+ through distinct pathways depending on local synaptic circuitry
Sign Up to like & getrecommendations! Published in 2017 at "Glia"
DOI: 10.1002/glia.23103
Abstract: Whilst astrocytes in culture invariably respond to dopamine with cytosolic Ca2+ rises, the dopamine sensitivity of astroglia in situ and its physiological roles remain unknown. To minimize effects of experimental manipulations on astroglial physiology, here… read more here.
Keywords: dopamine elevates; elevates lowers; dopamine; ca2 ... See more keywords
Augmented astrocyte microdomain Ca2+ dynamics and parenchymal arteriole tone in angiotensin II‐infused hypertensive mice
Sign Up to like & getrecommendations! Published in 2019 at "Glia"
DOI: 10.1002/glia.23564
Abstract: Hypertension is an important contributor to cognitive decline but the underlying mechanisms are unknown. Although much focus has been placed on the effect of hypertension on vascular function, less is understood of its effects on… read more here.
Keywords: ca2 dynamics; tone; ca2; hypertension ... See more keywords
Dilation of cortical capillaries is not related to astrocyte calcium signaling.
Sign Up to like & getrecommendations! Published in 2021 at "Glia"
DOI: 10.1002/glia.24119
Abstract: The brain requires an adequate supply of oxygen and nutrients to maintain proper function as neuronal activity varies. This is achieved, in part, through neurovascular coupling mechanisms that mediate local increases in blood flow through… read more here.
Keywords: astrocyte ca2; dilation; ca2 signaling; whisker stimulation ... See more keywords