Contributions of glutamate transporters and Ca2+-activated Cl- currents to feedback from horizontal cells to cone photoreceptors.
Sign Up to like & getrecommendations! Published in 2019 at "Experimental eye research"
DOI: 10.1016/j.exer.2019.107847
Abstract: Lateral inhibitory feedback from horizontal cells (HCs) to cones establishes center-surround receptive fields and color opponency in the retina. When HCs hyperpolarize to light, inhibitory feedback to cones increases activation of cone Ca2+ currents (ICa)… read more here.
Keywords: feedback horizontal; horizontal cells; ca2 activated; ca2 ... See more keywords
trans-δ-Viniferin inhibits Ca2+-activated Cl- channels and improves diarrhea symptoms.
Sign Up to like & getrecommendations! Published in 2019 at "Fitoterapia"
DOI: 10.1016/j.fitote.2019.104367
Abstract: Ca2+-activated Cl- channels (CaCCs) wildly exist in many tissues which play an important role in ion transport and excitation conduction, especially fluid secretion and smooth muscle contraction in epithelial tissues. TMEM16A as a classic CaCC… read more here.
Keywords: tvn; ca2 activated; diarrhea; viniferin inhibits ... See more keywords
The depressing role of sodium alginate in the flotation of Ca2+-activated quartz using fatty acid collector
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Liquids"
DOI: 10.1016/j.molliq.2021.117618
Abstract: Abstract The ions activation of quartz is a thorny problem that deteriorates the flotation of metal ore. Polymer inhibitors have exhibited excellent depression performance in the selective flotation of metal-ion activated minerals. In this study,… read more here.
Keywords: flotation ca2; ca2 activated; activated quartz; sodium ... See more keywords
Small conductance Ca2+-activated K+ channels in the plasma membrane, mitochondria and the ER: Pharmacology and implications in neuronal diseases
Sign Up to like & getrecommendations! Published in 2017 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2017.05.005
Abstract: Ca2+-activated K+ (KCa) channels regulate after-hyperpolarization in many types of neurons in the central and peripheral nervous system. Small conductance Ca2+-activated K+ (KCa2/SK) channels, a subfamily of KCa channels, are widely expressed in the nervous… read more here.
Keywords: small conductance; ca2 activated; pharmacology; conductance ca2 ... See more keywords
Atomistic mechanisms of the regulation of small-conductance Ca2+-activated K+ channel (SK2) by PIP2
Sign Up to like & getrecommendations! Published in 2024 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2318900121
Abstract: Significance Atrial fibrillation (AF) is the most common cardiac arrhythmia seen clinically and is associated with a significant increase in morbidity and mortality. Small-conductance Ca2+-activated K+ channels (SK, KCa2) are gated solely by intracellular Ca2+.… read more here.
Keywords: atomistic mechanisms; ca2 activated; small conductance; ca2 ... See more keywords
A potent and selective activator of large‐conductance Ca2+‐activated K+ channels induces preservation of mitochondrial function after hypoxia and reoxygenation by handling of calcium and transmembrane potential
Sign Up to like & getrecommendations! Published in 2024 at "Acta Physiologica"
DOI: 10.1111/apha.14151
Abstract: Ischaemic heart disease remains a significant cause of mortality globally. A pharmacological agent that protects cardiac mitochondria against oxygen deprivation injuries is welcome in therapy against acute myocardial infarction. Here, we evaluate the effect of… read more here.
Keywords: hypoxia reoxygenation; large conductance; ca2 activated; activated channels ... See more keywords
Inhibition of platelet aggregation by activation of platelet intermediate conductance Ca2+‐activated potassium channels
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15827
Abstract: Within the vasculature platelets and endothelial cells play crucial roles in hemostasis and thrombosis. Platelets, like endothelial cells, possess intermediate conductance Ca2+‐activated K+ (IKCa) channels and generate nitric oxide (NO). Although NO limits platelet aggregation,… read more here.
Keywords: conductance ca2; ca2 activated; intermediate conductance; platelet aggregation ... See more keywords
Adenylyl cyclase isoform 1 contributes to sinoatrial node automaticity via functional microdomains
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.162602
Abstract: Sinoatrial node (SAN) cells are the heart’s primary pacemaker. Their activity is tightly regulated by β-adrenergic receptor (β-AR) signaling. Adenylyl cyclase (AC) is a key enzyme in the β-AR pathway that catalyzes the production of… read more here.
Keywords: sinoatrial node; functional microdomains; isoform; adenylyl cyclase ... See more keywords
Neonatal exposure to sevoflurane caused learning and memory impairment via dysregulating SK2 channel endocytosis
Sign Up to like & getrecommendations! Published in 2021 at "Science Progress"
DOI: 10.1177/00368504211043763
Abstract: Numerous studies have demonstrated that anesthetics’ exposure to neonates imposes toxicity on the developing brain but the underlying mechanisms need to be further elucidated. Our present study aimed to explore the role of small conductance… read more here.
Keywords: activated potassium; small conductance; channel; ca2 activated ... See more keywords
Ca2+ activated cleavage of ezrin visualised dynamically in living myeloid cells during "cell surface area expansion".
Sign Up to like & getrecommendations! Published in 2020 at "Journal of cell science"
DOI: 10.1242/jcs.236968
Abstract: The intracellular events underlying phagocytosis, a crucial event for innate immunity, are still unresolved. In order to test whether the reservoir of membrane for the formation of the phagocytic pseudopodia is maintained by cortical ezrin,… read more here.
Keywords: expansion; cleavage; ca2 activated; ezrin ... See more keywords
Functional Roles of the Ca2+-activated K+ Channel, KCa3.1, in Brain Tumors
Sign Up to like & getrecommendations! Published in 2018 at "Current Neuropharmacology"
DOI: 10.2174/0929867324666170713103621
Abstract: Background Glioblastoma is the most aggressive and deadly brain tumor, with low disease-free period even after surgery and combined radio and chemotherapies. Among the factors contributing to the devastating effect of this tumor in the… read more here.
Keywords: channel kca3; kca3; activated channel; ca2 activated ... See more keywords