Opposing Intermolecular Tuning of Ca2+ Affinity for Calmodulin by Neurogranin and CaMKII Peptides
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2017.01.020
Abstract: We investigated the impact of bound calmodulin (CaM)-target compound structure on the affinity of calcium (Ca2+) by integrating coarse-grained models and all-atomistic simulations with nonequilibrium physics. We focused on binding between CaM and two specific… read more here.
Keywords: cam; ca2 affinity; camkii peptide; affinity ... See more keywords
Activity-Dependent Phosphorylation by CaMKIIδ Alters the Ca2+ Affinity of the Multi-C2-Domain Protein Otoferlin
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Synaptic Neuroscience"
DOI: 10.3389/fnsyn.2017.00013
Abstract: Otoferlin is essential for fast Ca2+-triggered transmitter release from auditory inner hair cells (IHCs), playing key roles in synaptic vesicle release, replenishment and retrieval. Dysfunction of otoferlin results in profound prelingual deafness. Despite its crucial… read more here.
Keywords: phosphorylation; otoferlin; camkii; ca2 affinity ... See more keywords