Tryptophan Scanning Mutagenesis of EF-Hand Motifs.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9030-6_35
Abstract: Ca2+ regulation in living systems occurs via specific structural alterations, subtle or drastic, in the Ca2+-binding domains of sensor proteins. Sensor proteins perform designated nonredundant roles within the dense network of Ca2+-binding proteins. A detailed… read more here.
Keywords: protein; mutagenesis; ca2 binding; hand ... See more keywords
An Update to Calcium Binding Proteins.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-12457-1_8
Abstract: Ca2+ binding proteins (CBP) are of key importance for calcium to play its role as a pivotal second messenger. CBP bind Ca2+ in specific domains, contributing to the regulation of its concentration at the cytosol… read more here.
Keywords: cbp; binding proteins; update calcium; ca2 binding ... See more keywords
Structure-Dynamic Coupling Through Ca2+-Binding Regulatory Domains of Mammalian NCX Isoform/Splice Variants.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-55858-5_3
Abstract: Mammalian Na+/Ca2+ exchangers (NCX1, NCX2, and NCX3) and their splice variants are expressed in a tissue-specific manner and are regulated by Ca2+ binding CBD1 and CBD2 domains. NCX2 does not undergo splicing, whereas in NCX1… read more here.
Keywords: cbds; splice variants; ca2 binding; ca2 ... See more keywords
Interrelation of Ca2+ and PE_PGRS proteins during Mycobacterium tuberculosis pathogenesis
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biosciences"
DOI: 10.1007/s12038-018-9828-4
Abstract: In today’s era tuberculosis is a major threat to human population. The lethality of this disease is caused by very efficiently thrived bacteria Mycobacterium tuberculosis (M. tuberculosis). Ca2+ plays crucial role in maintenance of cellular… read more here.
Keywords: pathogenesis; ca2 binding; interrelation ca2; tuberculosis ... See more keywords
Basic and editing mechanisms underlying ion transport and regulation in NCX variants.
Sign Up to like & getrecommendations! Published in 2019 at "Cell calcium"
DOI: 10.1016/j.ceca.2019.102131
Abstract: Structure-dynamic analysis of archaeal NCX (NCX_Mj) provided new insights into the underlying mechanisms of ion selectivity, ion-coupled alternating access, ion occlusion, and transport catalysis. This knowledge is relevant, not only for prokaryotic and eukaryotic NCXs,… read more here.
Keywords: ion transport; ca2 binding; ion; ncx variants ... See more keywords
A Leymus chinensis histidine-rich Ca2+-binding protein binds Ca2+/Zn2+ and suppresses abscisic acid signaling in Arabidopsis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of plant physiology"
DOI: 10.1016/j.jplph.2020.153209
Abstract: Intracellular Ca2+ plays an essential role in plant cellular sensing of various environmental stress signals by modulating the activity of Ca2+-binding proteins. Leymus chinensis is a dominant forage grass widely distributed in the Eurasian Steppe… read more here.
Keywords: histidine rich; ca2 binding; leymus chinensis; ca2 ... See more keywords
Ca2+-Binding Protein 1 Regulates Hippocampal-dependent Memory and Synaptic Plasticity
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2018.04.004
Abstract: Ca2+-binding protein 1 (CaBP1) is a Ca2+-sensing protein similar to calmodulin that potently regulates voltage-gated Ca2+ channels. Unlike calmodulin, however, CaBP1 is mainly expressed in neuronal cell-types and enriched in the hippocampus, where its function… read more here.
Keywords: protein; cabp1; ca2 binding; binding protein ... See more keywords
Intermotif Communication Induces Hierarchical Ca2+ Filling of Caldendrin.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemistry"
DOI: 10.1021/acs.biochem.7b00132
Abstract: A crucial event in calcium signaling is the transition of a calcium sensor from the apo (Ca2+ free) to the holo (Ca2+-saturated) state. Caldendrin (CDD) is a neuronal Ca2+-binding protein with two functional (EF3 and… read more here.
Keywords: state; intermotif communication; ca2 binding; ca2 ... See more keywords
How Pb2+ Binds and Modulates Properties of Ca2+-Signaling Proteins.
Sign Up to like & getrecommendations! Published in 2018 at "Inorganic chemistry"
DOI: 10.1021/acs.inorgchem.8b02548
Abstract: Abiogenic lead (Pb2+), present in the environment in elevated levels due to human activities, has detrimental effects on human health. Metal-binding sites in proteins have been identified as primary targets for lead substitution resulting in… read more here.
Keywords: pb2; ca2 binding; geometry; binding sites ... See more keywords
The Role of Calcium in Regulating the Conformational Dynamics of d-Galactose/d-Glucose-Binding Protein Revealed by Markov State Model Analysis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of chemical information and modeling"
DOI: 10.1021/acs.jcim.0c01119
Abstract: The d-glucose/d-galactose-binding protein (GGBP) from Escherichia coli is a substrate-binding protein (SBP) associated with sugar transport and chemotaxis. It is also a calcium-binding protein, which makes it unique in the SBP family. However, the functional… read more here.
Keywords: calcium; ca2 binding; ggbp; binding protein ... See more keywords
Dynamic interactions and Ca2+-binding modulate the holdase-type chaperone activity of S100B preventing tau aggregation and seeding
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-26584-2
Abstract: The microtubule-associated protein tau is implicated in the formation of oligomers and fibrillar aggregates that evade proteostasis control and spread from cell-to-cell. Tau pathology is accompanied by sustained neuroinflammation and, while the release of alarmin… read more here.
Keywords: tau aggregation; aggregation; tau; ca2 binding ... See more keywords