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1
Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.06.035
Abstract: ABSTRACT Ca2+ plays a major role in maintaining cellular homeostasis and regulates processes including apoptotic cell death and side‐effects of cancer chemotherapy including vomiting. Currently we explored the emetic mechanisms of FPL64176, an L‐type Ca2+…
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Keywords:
ca2 channel;
type ca2;
ca2;
fpl64176 induced ... See more keywords
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1
Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-18947-y
Abstract: The L-type Ca2+ channel CaV1.2 is essential for arterial myocyte excitability, gene expression and contraction. Elevations in extracellular glucose (hyperglycemia) potentiate vascular L-type Ca2+ channel via PKA, but the underlying mechanisms are unclear. Here, we…
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Keywords:
ca2 channel;
cav1;
type ca2;
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1
Published in 2019 at "British journal of pharmacology"
DOI: 10.1111/bph.14788
Abstract: BACKGROUND AND PURPOSE Mibefradil (Mib), a T-type Ca2+ channel blocker, has been investigated for treating solid tumours. However, its underlying mechanisms are still unclear. Here we aimed to investigate the pharmacological aspect of Mib on…
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Keywords:
channel blocker;
mib;
channel;
ca2 channel ... See more keywords
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0
Published in 2019 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.14851
Abstract: β‐Subunits of the Ca2+ channel have been conventionally regarded as auxiliary subunits that regulate the expression and activity of the pore‐forming α1 subunit. However, they comprise protein–protein interaction domains, such as a SRC homology 3…
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Keywords:
chromaffin cells;
sh3;
ca2 channel;
subunit ... See more keywords
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1
Published in 2020 at "Science signaling"
DOI: 10.1126/scisignal.abc6438
Abstract: Ca2+ influx through the L-type Ca2+ channel Cav1.2 triggers each heartbeat. The fight-or-flight response induces the release of the stress response hormone norepinephrine to stimulate β-adrenergic receptors, cAMP production, and protein kinase A activity to…
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Keywords:
channel cav1;
ca2 channel;
cav1;
type ca2 ... See more keywords
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2
Published in 2022 at "Science Signaling"
DOI: 10.1126/scisignal.abq5594
Abstract: Calcium (Ca2+) signaling has long been known to be crucial for T cell activation. Erdogmus et al. tested the function of voltage-gated Ca2+ channel (CaV) proteins and discovered a nonchannel function mediated by an accessory…
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Keywords:
channel proteins;
voltage gated;
ca2 channel;
gated ca2 ... See more keywords
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1
Published in 2019 at "Annual review of pharmacology and toxicology"
DOI: 10.1146/annurev-pharmtox-010919-023404
Abstract: Formation of signaling complexes is crucial for the orchestration of fast, efficient, and specific signal transduction. Pharmacological disruption of defined signaling complexes has the potential for specific intervention in selected regulatory pathways without affecting organism-wide…
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Keywords:
channel cav1;
pharmacology;
ca2 channel;
type ca2 ... See more keywords
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Published in 2018 at "Journal of neurophysiology"
DOI: 10.1152/jn.00285.2018
Abstract: Magnocellular oxytocin (OT) and vasopressin (VP) neurons express an afterhyperpolarization (AHP) following spike trains that attenuates firing rate and contributes to burst patterning. This AHP includes contributions from an apamin-sensitive, medium-duration AHP (mAHP) and from…
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Keywords:
voltage;
ahp;
ca2 channel;
ca2 ... See more keywords
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Published in 2020 at "Journal of Cell Science"
DOI: 10.1242/jcs.241752
Abstract: ABSTRACT Ras–Erk MAPK signaling controls many of the principal pathways involved in metazoan cell motility, drives metastasis of multiple cancer types and is targeted in chemotherapy. However, its putative roles in immune cell functions or…
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Keywords:
toxoplasma;
gated ca2;
dendritic cells;
ca2 channel ... See more keywords
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1
Published in 2022 at "Physiological Reports"
DOI: 10.14814/phy2.15306
Abstract: Orai1 is a ubiquitously‐expressed plasma membrane Ca2+ channel that is involved in store‐operated Ca2+ entry (SOCE): a fundamental biological process that regulates gene expression, the onset of inflammation, secretion, and the contraction of airway smooth…
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Keywords:
ca2;
orai1;
ca2 channel;
splunc1 ... See more keywords
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Published in 2018 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2018.00062
Abstract: Background: We previously have proved that sodium tanshinone II-A sulfonate (DS-201), a derivative of traditional Chinese medicinal herb Danshen (Salvia miltiorrhiza), is an opener and vasodilator of BKCa channel in the vascular smooth muscle cells…
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Keywords:
type ca2;
vasorelaxation;
ca2 channel;
ca2 ... See more keywords