Phosphorylation states greatly regulate the activity and gating properties of Cav3.1 T‐type Ca2+ channels
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.30920
Abstract: Cav3.1 T‐type Ca2+ channels play pivotal roles in neuronal low‐threshold spikes, visceral pain, and pacemaker activity. Phosphorylation has been reported to potently regulate the activity and gating properties of Cav3.1 channels. However, systematic identification of… read more here.
Keywords: cav3 type; type ca2; activity; ca2 channels ... See more keywords
Astroglial Ca2+ signaling is generated by the coordination of IP3R and store-operated Ca2+ channels.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.03.096
Abstract: Astrocytes play key roles in the central nervous system and regulate local blood flow and synaptic transmission via intracellular calcium (Ca2+) signaling. Astrocytic Ca2+ signals are generated by multiple pathways: Ca2+ release from the endoplasmic… read more here.
Keywords: store operated; ca2 signaling; astrocytic ca2; ca2 ... See more keywords
Regulation and function of AP-1 in insulinoma cells and pancreatic β-cells.
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2021.114748
Abstract: Cav1.2 L-type voltage-gated Ca2+ channels play a central role in pancreatic β-cells by integrating extracellular signals with intracellular signaling events leading to insulin secretion and altered gene transcription. Here, we investigated the intracellular signaling pathway… read more here.
Keywords: transcription; insulinoma cells; cav1 ca2; pancreatic cells ... See more keywords
Optical control of L-type Ca2+ channels using a diltiazem photoswitch
Sign Up to like & getrecommendations! Published in 2018 at "Nature Chemical Biology"
DOI: 10.1038/s41589-018-0090-8
Abstract: L-type Ca2+ channels (LTCCs) play a crucial role in excitation–contraction coupling and release of hormones from secretory cells. They are targets of antihypertensive and antiarrhythmic drugs such as diltiazem. Here, we present a photoswitchable diltiazem,… read more here.
Keywords: ca2 channels; optical control; type ca2; ca2 ... See more keywords
A novel phospho-modulatory mechanism contributes to the calcium-dependent regulation of T-type Ca2+ channels
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-52194-6
Abstract: Cav3 / T-type Ca2+ channels are dynamically regulated by intracellular Ca2+ ions, which inhibit Cav3 availability. Here, we demonstrate that this inhibition becomes irreversible in the presence of non-hydrolysable ATP analogs, resulting in a strong… read more here.
Keywords: mechanism; cav3; type ca2; ca2 ... See more keywords
Differential Regulation of Human Paired Associative Stimulation-Induced and Theta-Burst Stimulation-Induced Plasticity by L-type and T-type Ca2+ Channels
Sign Up to like & getrecommendations! Published in 2017 at "Cerebral Cortex"
DOI: 10.1093/cercor/bhw212
Abstract: Activity-dependent changes of postsynaptic Ca2+-concentration are influenced by a variety of different Ca2+-channels and play an important role in synaptic plasticity. Paired associative stimulation (PAS) and theta-burst stimulation (TBS) are noninvasive magnetic stimulation protocols used… read more here.
Keywords: stimulation; type; plasticity; induced plasticity ... See more keywords
Ca2+ channels couple spiking to mitochondrial metabolism in substantia nigra dopaminergic neurons
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abp8701
Abstract: How do neurons match generation of adenosine triphosphate by mitochondria to the bioenergetic demands of regenerative activity? Although the subject of speculation, this coupling is still poorly understood, particularly in neurons that are tonically active.… read more here.
Keywords: couple spiking; nigra dopaminergic; channels couple; substantia nigra ... See more keywords
Interactive nanocluster compaction of the ELKS scaffold and Cacophony Ca2+ channels drives sustained active zone potentiation
Sign Up to like & getrecommendations! Published in 2023 at "Science Advances"
DOI: 10.1126/sciadv.ade7804
Abstract: At presynaptic active zones (AZs), conserved scaffold protein architectures control synaptic vesicle (SV) release by defining the nanoscale distribution and density of voltage-gated Ca2+ channels (VGCCs). While AZs can potentiate SV release in the minutes… read more here.
Keywords: nanoscale distribution; interactive nanocluster; potentiation; ca2 channels ... See more keywords
Loose Coupling Between SK and P/Q-type Ca2+ Channels in Cartwheel Cells of the Dorsal Cochlear Nucleus.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of neurophysiology"
DOI: 10.1152/jn.00515.2019
Abstract: Small-conductance Ca2+-activated K+ (SK) and large conductance, voltage- and Ca2+-activated K+ (BK) channels are Ca2+-activated K+ channels that control action potential firing diverse neurons in the brain. In cartwheel cells of the dorsal cochlear nucleus,… read more here.
Keywords: cells dorsal; type ca2; ca2; cartwheel cells ... See more keywords
PIP2 alters of Ca2+ currents in acutely dissociated supraoptic oxytocin neurons
Sign Up to like & getrecommendations! Published in 2019 at "Physiological Reports"
DOI: 10.14814/phy2.14198
Abstract: Magnocellular neurosecretory cells (MNCs) occupying the supraoptic nucleus (SON) contain voltage‐gated Ca2+ channels that provide Ca2+ for triggering vesicle release, initiating signaling pathways, and activating channels, such as the potassium channels underlying the afterhyperpolarization (AHP).… read more here.
Keywords: channel currents; alters ca2; ca2; pip2 alters ... See more keywords
L-Type Ca2+ Channels of NG2 Glia Determine Proliferation and NMDA Receptor-Dependent Plasticity
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.759477
Abstract: NG2 (nerve/glial antigen 2) glia are uniformly distributed in the gray and white matter of the central nervous system (CNS). They are the major proliferating cells in the brain and can differentiate into oligodendrocytes. NG2… read more here.
Keywords: ng2 glia; proliferation; cav1; type vgccs ... See more keywords