Intracellular calcium leak lowers glucose storage in human muscle, promoting hyperglycemia and diabetes
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DOI: 10.7554/elife.53999
Abstract: Most glucose is processed in muscle, for energy or glycogen stores. Malignant Hyperthermia Susceptibility (MHS) exemplifies muscle conditions that increase [Ca2+]cytosol. 42% of MHS patients have hyperglycemia. We show that phosphorylated glycogen phosphorylase (GPa), glycogen… read more here.
Keywords: calcium leak; intracellular calcium; muscle; ca2 cytosol ... See more keywords