Calmodulin promotes a Ca2+‐dependent conformational change in the C‐terminal regulatory domain of CaV1.2
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Letters"
DOI: 10.1002/1873-3468.14529
Abstract: Calmodulin (CaM) binds to the membrane‐proximal cytosolic C‐terminal domain of CaV1.2 (residues 1520–1669, CT(1520–1669)) and causes Ca2+‐induced conformational changes that promote Ca2+‐dependent channel inactivation (CDI). We report biophysical studies that probe the structural interaction between… read more here.
Keywords: domain cav1; ca2 dependent; 1520 1669; cam ... See more keywords
Ca2+-Dependent Regulation of TFEB and Lysosomal Function.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9018-4_13
Abstract: Lysosomes are emerging as calcium store organelles that can modulate various intracellular processes such as the regulation of nutrient signaling through the activation of TFEB, a master gene for lysosomal function, or very specialized functions… read more here.
Keywords: tfeb; ca2 dependent; tfeb lysosomal; lysosomal function ... See more keywords
Structure-Dynamic Coupling Through Ca2+-Binding Regulatory Domains of Mammalian NCX Isoform/Splice Variants.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-55858-5_3
Abstract: Mammalian Na+/Ca2+ exchangers (NCX1, NCX2, and NCX3) and their splice variants are expressed in a tissue-specific manner and are regulated by Ca2+ binding CBD1 and CBD2 domains. NCX2 does not undergo splicing, whereas in NCX1… read more here.
Keywords: cbds; splice variants; ca2 binding; ca2 ... See more keywords
Cadmium Impairs Autophagy Leading to Apoptosis by Ca2+-Dependent Activation of JNK Signaling Pathway in Neuronal Cells.
Sign Up to like & getrecommendations! Published in 2021 at "Neurochemical research"
DOI: 10.1007/s11064-021-03341-x
Abstract: Autophagy, a process for self-degradation of intracellular components and dysfunctional organelles, is closely related with neurodegenerative diseases. It has been shown that cadmium (Cd) induces neurotoxicity partly by impairing autophagy. However, the underlying mechanism is… read more here.
Keywords: neuronal cells; expansion; jnk; ca2 ... See more keywords
Fast and slow Ca2+-dependent hyperpolarization mechanisms connect membrane potential and sleep homeostasis
Sign Up to like & getrecommendations! Published in 2017 at "Current Opinion in Neurobiology"
DOI: 10.1016/j.conb.2017.05.007
Abstract: Several lines of evidence indicate that the sleep-wake state of cortical neurons is regulated not only through neuronal projections from the lower brain, but also through the cortical neurons' intrinsic ability to initiate a slow… read more here.
Keywords: dependent hyperpolarization; hyperpolarization mechanisms; ca2 dependent; membrane potential ... See more keywords
Analysis of gene expression in Ca2+-dependent activator protein for secretion 2 (Cadps2) knockout cerebellum using GeneChip and KEGG pathways
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2016.12.068
Abstract: In the mouse cerebellum, Ca2+-dependent activator protein for secretion 2 (CADPS2, CAPS2) is involved in regulated secretion from dense-core vesicles (DCVs), which contain neuropeptides including brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3). Capds2 knockout (KO)… read more here.
Keywords: secretion; gene expression; expression; cerebellum ... See more keywords
Calpain inhibition reduces NMDA receptor rundown in rat substantia nigra dopamine neurons
Sign Up to like & getrecommendations! Published in 2018 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2018.05.003
Abstract: &NA; Repeated activation of N‐Methyl‐D‐aspartate receptors (NMDARs) causes a Ca2+‐dependent reduction in NMDAR‐mediated current in dopamine (DA) neurons of the substantia nigra pars compacta (SNc) in one week old rats; however, a Ca2+‐dependent regulatory protein… read more here.
Keywords: nmdar current; ca2 dependent; calpain; current rundown ... See more keywords
Fluvastatin inhibits Rab5-mediated IKs internalization caused by chronic Ca2+-dependent PKC activation.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2019.03.016
Abstract: Statins, in addition to their cholesterol lowering effects, can prevent isoprenylation of Rab GTPase proteins, a key protein family for the regulation of protein trafficking. Rab-GTPases have been shown to be involved in the control… read more here.
Keywords: ca2 dependent; function; dependent pkc; cpkc ... See more keywords
Ca2+-dependent modulation of voltage-gated myocyte sodium channels
Sign Up to like & getrecommendations! Published in 2021 at "Biochemical Society Transactions"
DOI: 10.1042/bst20200604
Abstract: Voltage-dependent Na+ channel activation underlies action potential generation fundamental to cellular excitability. In skeletal and cardiac muscle this triggers contraction via ryanodine-receptor (RyR)-mediated sarcoplasmic reticular (SR) Ca2+ release. We here review potential feedback actions of… read more here.
Keywords: skeletal cardiac; voltage; ca2 dependent; action potential ... See more keywords
TRPM4 inhibition by meclofenamate suppresses Ca2+-dependent triggered arrhythmias.
Sign Up to like & getrecommendations! Published in 2022 at "European heart journal"
DOI: 10.1093/eurheartj/ehac354
Abstract: AIMS Cardiac arrhythmias are a major factor in the occurrence of morbidity and sudden death in patients with cardiovascular disease. Disturbances of Ca2+ homeostasis in the heart contribute to the initiation and maintenance of cardiac… read more here.
Keywords: arrhythmias trpm4; trpm4; dependent triggered; ca2 dependent ... See more keywords
E. coli RNase I exhibits a strong Ca2+-dependent inherent double-stranded RNase activity
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab284
Abstract: Abstract Since its initial characterization, Escherichia coli RNase I has been described as a single-strand specific RNA endonuclease that cleaves its substrate in a largely sequence independent manner. Here, we describe a strong calcium (Ca2+)-dependent… read more here.
Keywords: rnase; double stranded; activity; ca2 dependent ... See more keywords