STIM-TRP Pathways and Microdomain Organization: Contribution of TRPC1 in Store-Operated Ca2+ Entry: Impact on Ca2+ Signaling and Cell Function.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-57732-6_9
Abstract: Store-operated calcium entry (SOCE) is a ubiquitous Ca2+ entry pathway that is activated in response to depletion of ER-Ca2+ stores and critically controls the regulation of physiological functions in a wide variety of cell types.… read more here.
Keywords: store operated; trpc1; function; store ... See more keywords
Mitsugumin 53 Regulates Extracellular Ca2+ Entry and Intracellular CA2+ Release via Orai1 and RyR1 in Skeletal Muscle
Sign Up to like & getrecommendations! Published in 2017 at "Biophysical Journal"
DOI: 10.1016/j.bpj.2016.11.568
Abstract: Mitsugumin 53 (MG53) participates in the membrane repair of various cells, and skeletal muscle is the major tissue that expresses MG53. Except for the regulatory effects of MG53 on SERCA1a, the role(s) of MG53 in… read more here.
Keywords: skeletal muscle; mg53; muscle; extracellular ca2 ... See more keywords
Store-operated Ca2+ entry regulates neuronal gene expression and function
Sign Up to like & getrecommendations! Published in 2022 at "Current Opinion in Neurobiology"
DOI: 10.1016/j.conb.2022.01.005
Abstract: Recent studies with mutants of STIM and Orai have identified store-operated Ca2+ entry as an important regulator of neuronal function in Drosophila and mouse. Cellular Ca2+ imaging and electrophysiological studies demonstrate changes in ion channel… read more here.
Keywords: store; expression; operated ca2; ca2 entry ... See more keywords
Resolving macrophage polarization through distinct Ca2+ entry channel that maintains intracellular signaling and mitochondrial bioenergetics
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DOI: 10.1016/j.isci.2021.103339
Abstract: Summary Transformation of naive macrophages into classically (M1) or alternatively (M2) activated macrophages regulates the inflammatory response. Here, we identified that distinct Ca2+ entry channels determine the IFNγ-induced M1 or IL-4-induced M2 transition. Naive or… read more here.
Keywords: distinct ca2; macrophage polarization; entry; ca2 entry ... See more keywords
Bcl-2 regulates store-operated Ca2+ entry to modulate ER stress-induced apoptosis
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DOI: 10.1038/s41420-018-0039-4
Abstract: Ca2+ plays a significant role in linking the induction of apoptosis. The key anti-apoptotic protein, Bcl-2, has been reported to regulate the movement of Ca2+ across the ER membrane, but the exact effect of Bcl-2… read more here.
Keywords: apoptosis; stress; bcl; soce ... See more keywords
Store-operated Ca2+ Entry Facilitates the Lipopolysaccharide-induced Cyclooxygenase-2 Expression in Gastric Cancer Cells
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-12648-1
Abstract: Helicobacter pylori has been identified as one of the major causes of chronic gastritis, gastric and duodenal ulcers, and gastric cancer. Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria, and… read more here.
Keywords: store operated; gastric cancer; operated ca2; cancer ... See more keywords
A muscular hypotonia-associated STIM1 mutant at R429 induces abnormalities in intracellular Ca2+ movement and extracellular Ca2+ entry in skeletal muscle
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-55745-z
Abstract: Stromal interaction molecule 1 (STIM1) mediates extracellular Ca2+ entry into the cytosol through a store-operated Ca2+ entry (SOCE) mechanism, which is involved in the physiological functions of various tissues, including skeletal muscle. STIM1 is also… read more here.
Keywords: skeletal muscle; stim1; extracellular ca2; ca2 ... See more keywords
Store-operated Ca2+ entry in primary murine lung fibroblasts is independent of classical transient receptor potential (TRPC) channels and contributes to cell migration
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DOI: 10.1038/s41598-020-63677-2
Abstract: Stromal interaction molecules (STIM1, 2) are acting as sensors for Ca2+ in intracellular stores and activate Orai channels at the plasma membrane for store-operated Ca2+ entry (SOCE), while classical transient receptor potential (TRPC) channel mediate… read more here.
Keywords: trpc; operated ca2; pmlf; receptor ... See more keywords
ER-resident STIM1/2 couples Ca2+ entry by NMDA receptors to pannexin-1 activation
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2112870119
Abstract: Significance Pannexin-1 (Panx1) channels contribute to neurological disorders, including stroke and epilepsy, where their function has been linked to N-methyl D-aspartate (NMDA) receptors (NMDARs). We discovered that Ca2+ entry via NMDARs recruits endoplasmic reticulum–resident STIM… read more here.
Keywords: activation; nmda receptors; panx1; ca2 entry ... See more keywords
Ca2+ entry through mechanotransduction channels localizes BAIAP2L2 to stereocilia tips
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e21-10-0491
Abstract: Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 2 (BAIAP2L2), a membrane-binding protein required for the maintenance of mechanotransduction in hair cells, is selectively retained at the tips of transducing stereocilia. BAIAP2L2 trafficked to stereocilia tips… read more here.
Keywords: baiap2l2; stereocilia tips; mechanotransduction; ca2 entry ... See more keywords
RyR2 regulates store-operated Ca2+ entry, phospholipase C activity, and electrical excitability in the insulinoma cell line INS-1
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DOI: 10.1101/2022.10.19.512717
Abstract: The ER Ca2+ channel ryanodine receptor 2 (RyR2) is required for maintenance of insulin content and glucose-stimulated insulin secretion, in part, via regulation of the protein IRBIT in the insulinoma cell line INS-1. Here, we… read more here.
Keywords: cell; activity; ca2 entry; cells compared ... See more keywords