Allosteric regulators selectively prevent Ca2+-feedback of CaV and NaV channels
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DOI: 10.7554/elife.35222
Abstract: Calmodulin (CaM) serves as a pervasive regulatory subunit of CaV1, CaV2, and NaV1 channels, exploiting a functionally conserved carboxy-tail element to afford dynamic Ca2+-feedback of cellular excitability in neurons and cardiomyocytes. Yet this modularity counters… read more here.
Keywords: cam; regulators selectively; allosteric regulators; ca2 feedback ... See more keywords