Neurokinin-1 Receptor Signaling Is Required for Efficient Ca2+ Flux in T-Cell-Receptor-Activated T Cells
Sign Up to like & getrecommendations! Published in 2020 at "Cell reports"
DOI: 10.1016/j.celrep.2020.02.054
Abstract: SUMMARY Efficient Ca2+ flux induced during cognate T cell activation requires signaling the T cell receptor (TCR) and unidentified G-protein-coupled receptors (GPCRs). T cells express the neurokinin-1 receptor (NK1R), a GPCR that mediates Ca2+ flux… read more here.
Keywords: receptor; ca2 flux; efficient ca2; activated cells ... See more keywords
BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature22798
Abstract: BRCA1-associated protein 1 (BAP1) is a potent tumour suppressor gene that modulates environmental carcinogenesis. All carriers of inherited heterozygous germline BAP1-inactivating mutations (BAP1+/−) developed one and often several BAP1−/− malignancies in their lifetime, mostly malignant… read more here.
Keywords: bap1 regulates; regulates ip3r3; bap1; ca2 flux ... See more keywords
The cell-wide web coordinates cellular processes by directing site-specific Ca2+ flux across cytoplasmic nanocourses
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-10055-w
Abstract: Ca2+ coordinates diverse cellular processes, yet how function-specific signals arise is enigmatic. We describe a cell-wide network of distinct cytoplasmic nanocourses with the nucleus at its centre, demarcated by sarcoplasmic reticulum (SR) junctions (≤400 nm across)… read more here.
Keywords: specific ca2; cytoplasmic nanocourses; ca2 flux; ca2 ... See more keywords
Phospholipase Cγ2 is critical for Ca2+ flux and cytokine production in anti-fungal innate immunity of human corneal epithelial cells
Sign Up to like & getrecommendations! Published in 2018 at "BMC Ophthalmology"
DOI: 10.1186/s12886-018-0847-6
Abstract: BackgroundFungal keratitis (FK) is a sight-threatening disease, accounting for a significant portion with its complex presentation, suboptimal efficacy of the existing therapies and uncontrollable excessive innate inflammation. Phospholipase C-γ2 (PLCγ2) is a non-receptor tyrosine kinase… read more here.
Keywords: innate; ca2 flux; hcecs; fumigatus hyphae ... See more keywords
SEC24A facilitates colocalization and Ca2+ flux between the endoplasmic reticulum and mitochondria
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cell Science"
DOI: 10.1242/jcs.249276
Abstract: ABSTRACT A genome-wide screen recently identified SEC24A as a novel mediator of thapsigargin-induced cell death in HAP1 cells. Here, we determined the cellular mechanism and specificity of SEC24A-mediated cytotoxicity. Measurement of Ca2+ levels using organelle-specific… read more here.
Keywords: endoplasmic reticulum; ca2 flux; sec24a; ca2 ... See more keywords
Inhibitory Receptor Crosslinking Quantitatively Dampens Calcium Flux Induced by Activating Receptor Triggering in NK Cells
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2018.03173
Abstract: Natural killer (NK) cell function is regulated by a balance between activating and inhibitory receptors, but the details of this receptor interplay are not extensively understood. We developed a flow cytometry-based assay system in which… read more here.
Keywords: activating receptor; receptor triggering; ca2 flux; receptor ... See more keywords
Sport Performance and Manual Therapies: A Review on the Effects on Mitochondrial, Sarcoplasmatic and Ca2+ Flux Response
Sign Up to like & getrecommendations! Published in 2021 at "Healthcare"
DOI: 10.3390/healthcare9020181
Abstract: The present narrative review aims to highlight the possible effects manual therapies could have on cells and mitochondria, as these effects could improve athletic performance management. To this aim, this review summarizes the relationship between… read more here.
Keywords: ca2 flux; manual therapies; response; performance ... See more keywords
Synthesis, Biological Evaluation, and Molecular Modeling of Aza-Crown Ethers
Sign Up to like & getrecommendations! Published in 2021 at "Molecules"
DOI: 10.3390/molecules26082225
Abstract: Synthetic and natural ionophores have been developed to catalyze ion transport and have been shown to exhibit a variety of biological effects. We synthesized 24 aza- and diaza-crown ethers containing adamantyl, adamantylalkyl, aminomethylbenzoyl, and ε-aminocaproyl… read more here.
Keywords: diaza crown; ca2 flux; ca2; aza crown ... See more keywords