Calcium-handling abnormalities underlying atrial arrhythmogenesis in a Fontan operation canine model
Sign Up to like & getrecommendations! Published in 2018 at "World Journal of Pediatrics"
DOI: 10.1007/s12519-018-0177-z
Abstract: BackgroundAtrial tachyarrhythmia (AT) is a common complication in patients who have undergone a Fontan operation. In this study, we investigated whether abnormal Ca2+ handling contributes to the Fontan operation-related atrial arrhythmogenic substrate.MethodsMongrel dogs were randomly… read more here.
Keywords: fontan operation; handling abnormalities; ca2 handling; ca2 ... See more keywords
Analysis of neuronal Ca2+ handling properties by combining perforated patch clamp recordings and the added buffer approach.
Sign Up to like & getrecommendations! Published in 2021 at "Cell calcium"
DOI: 10.1016/j.ceca.2021.102411
Abstract: Ca2+ functions as an important intracellular signal for a wide range of cellular processes. These processes are selectively activated by controlled spatiotemporal dynamics of the free cytosolic Ca2+. Intracellular Ca2+ dynamics are regulated by numerous… read more here.
Keywords: buffer approach; added buffer; ca2 handling; ca2 ... See more keywords
(‐)‐Terpinen‐4‐ol changes intracellular Ca2+ handling and induces pacing disturbance in rat hearts
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2017.04.022
Abstract: Abstract (‐)‐Terpinen‐4‐ol is a naturally occurring plant monoterpene and has been shown to have a plethora of biological activities. The objective of this study was to investigate the effects of (‐)‐terpinen‐4‐ol on the rat heart,… read more here.
Keywords: terpinen; ca2 handling; effect; ca2 ... See more keywords
Ion Channels of the Islets in Type 2 Diabetes.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.08.014
Abstract: Ca2+ is an essential signal for pancreatic β-cell function. Ca2+ plays critical roles in numerous β-cell pathways such as insulin secretion, transcription, metabolism, endoplasmic reticulum function and the stress response. Therefore, β-cell Ca2+ handling is… read more here.
Keywords: ion channels; ca2 handling; type diabetes; ca2 ... See more keywords
4968Increased Gao expression underlies cardiac dysfunction and lethal arrhythmias accompanied with abnormal Ca2+ handling
Sign Up to like & getrecommendations! Published in 2019 at "European Heart Journal"
DOI: 10.1093/eurheartj/ehz746.0027
Abstract: We previously demonstrated that a transcriptional repressor, neuron restrictive silencer factor (NRSF), maintains normal cardiac function and electrical stability. Transgenic mice expressing a dominant-negative mutant of NRSF in their hearts (dnNRSF-Tg) exhibit systolic dysfunction with… read more here.
Keywords: dysfunction; ca2 handling; lethal arrhythmias; expression ... See more keywords
Sex differences in mitochondrial Ca2+ handling in mouse fast-twitch skeletal muscle in vivo.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of applied physiology"
DOI: 10.1152/japplphysiol.00230.2019
Abstract: We investigated sex differences in mitochondrial Ca2+handling properties in mouse fast twitch skeletal muscle. Changes in cytoplasmicCa2+concentration ([Ca2+]cyto) were measured in vivo using tibialis anterior muscles from male and female mice. The muscles were exposed… read more here.
Keywords: sex differences; ca2 handling; differences mitochondrial; ca2 ... See more keywords
Abstract 240: Mistrafficking of Integrin β1d Contributes to Ca2+handling Disorder and Catecholaminergic Polymorphic Ventricular Tachycardia Under Cardiac Stress
Sign Up to like & getrecommendations! Published in 2019 at "Circulation Research"
DOI: 10.1161/res.125.suppl_1.240
Abstract: Background: RyR2 hyper-phosphorylation has been identified as a contributing mechanism to arrhythmogenesis. The integrin β1D colocalized with RyR2 and stabilized phosphorylation of RyR2, which maintains the function of the RyR2 channel. Our objective is to… read more here.
Keywords: ryr2; ca2 handling; cardiac stress; integrin ... See more keywords
Targeting Ca2 + Handling Proteins for the Treatment of Heart Failure and Arrhythmias
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2020.01068
Abstract: Diseases of the heart, such as heart failure and cardiac arrhythmias, are a growing socio-economic burden. Calcium (Ca2+) dysregulation is key hallmark of the failing myocardium and has long been touted as a potential therapeutic… read more here.
Keywords: heart; handling proteins; ca2 handling; heart failure ... See more keywords
Cardiac Pacemaker Dysfunction Arising From Different Studies of Ion Channel Remodeling in the Aging Rat Heart
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2020.546508
Abstract: The function of the sinoatrial node (SAN), the pacemaker of the heart, declines with age, resulting in increased incidence of sinoatrial node dysfunction (SND) in older adults. The present study assesses potential ionic mechanisms underlying… read more here.
Keywords: ion channels; ca2 handling; study; aging study ... See more keywords