Co-targeting Mitochondrial Ca2+ Homeostasis and Autophagy Enhances Cancer Cells' Chemosensitivity
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.101263
Abstract: Summary Mitochondria are important cell death checkpoints, and mitochondrial Ca2+ overload is considered as a potent apoptotic intrinsic pathway inducer. Here, we report that this Ca2+ apoptosis link is largely ineffective in inducing cell-death just… read more here.
Keywords: autophagy; ca2; cancer cells; ca2 homeostasis ... See more keywords
Shed CNTNAP2 ectodomain is detectable in CSF and regulates Ca2+ homeostasis and network synchrony via PMCA2/ATP2B2
Sign Up to like & getrecommendations! Published in 2022 at "Neuron"
DOI: 10.1016/j.neuron.2021.11.025
Abstract: Although many neuronal membrane proteins undergo proteolytic cleavage, little is known about the biological significance of neuronal ectodomain shedding (ES). Here, we show that the neuronal sheddome is detectable in human cerebrospinal fluid (hCSF) and… read more here.
Keywords: ectodomain; ca2 homeostasis; network synchrony; cntnap2 ecto ... See more keywords
Antiproliferative effect of a benzofuran derivate based on the structure of amiodarone on Leishmania donovani affecting mitochondria, acidocalcisomes and intracellular Ca2+ homeostasis.
Sign Up to like & getrecommendations! Published in 2019 at "Parasitology international"
DOI: 10.1016/j.parint.2019.02.006
Abstract: Leishmaniasis is a parasitic disease representing an important problem of public health. Visceral leishmaniasis, resulting from infection with Leishmania donovani, causes considerable mortality and morbidity in the poorest region of the word. At present there… read more here.
Keywords: intracellular ca2; leishmania donovani; ca2 homeostasis; ca2 ... See more keywords
iASPP suppresses Gp78-mediated TMCO1 degradation to maintain Ca2+ homeostasis and control tumor growth and drug resistance
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2111380119
Abstract: Significance Accumulating preclinical and clinical evidence has supported a central role for alterations in Ca2+ homeostasis in the development of cancer. TMCO1 protein is an identified Ca2+-channel protein, while its roles in cancer remain obscure.… read more here.
Keywords: iaspp tmco1; cancer; ca2 homeostasis; degradation ... See more keywords
Systematic analysis of Ca2+ homeostasis in Saccharomyces cerevisiae based on chemical-genetic interaction profiles
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e17-04-0216
Abstract: The global landscape of Ca2+ homeostasis in budding yeast is deciphered. Quantified morphological responses under high concentration of Ca2+ and obtained high-dimensional Ca2+-genetic interaction profiles show functional gene clusters, which are used to build a… read more here.
Keywords: homeostasis; ca2 homeostasis; interaction profiles; genetic interaction ... See more keywords
Reticulocalbin3: A Ca2+ homeostasis regulator that promotes esophageal squamous cell carcinoma progression and cisplatin resistance
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15487
Abstract: Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent cancers worldwide. There is a critical need to identify new mechanisms that contribute to ESCC progression. Reticulocalbin3 (RCN3) is mainly located in the endoplasmic… read more here.
Keywords: ca2 homeostasis; progression; reticulocalbin3; resistance ... See more keywords
Cardiomyocyte beta2AR mediates cardiac fibrosis via maintaining Ca2+ homeostasis in the heart
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5734697
Abstract: Objective: Cardiac beta2-adrenoceptor (β2AR) has been suggested functions a protective role in defending myocyte apoptosis and cardiac damage induced by various stress. Our recent studies indicate divergent roles of cardiac β2AR in cardiomyocytes and myofibroblasts… read more here.
Keywords: ca2 homeostasis; cardiac fibrosis; cardiomyocyte; physiology ... See more keywords
OPA1 Modulates Mitochondrial Ca2+ Uptake Through ER-Mitochondria Coupling
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.774108
Abstract: Autosomal Dominant Optic Atrophy (ADOA), a disease that causes blindness and other neurological disorders, is linked to OPA1 mutations. OPA1, dependent on its GTPase and GED domains, governs inner mitochondrial membrane (IMM) fusion and cristae… read more here.
Keywords: ca2 homeostasis; mitochondria coupling; opa1; opa1 modulates ... See more keywords
Severe acute respiratory syndrome coronavirus-2 accessory proteins ORF3a and ORF7a modulate autophagic flux and Ca2+ homeostasis in yeast
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2023.1152249
Abstract: Virus infection involves the manipulation of key host cell functions by specialized virulence proteins. The Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) small accessory proteins ORF3a and ORF7a have been implicated in favoring virus replication and… read more here.
Keywords: orf3a orf7a; ca2 homeostasis; autophagic flux; accessory proteins ... See more keywords
Selenium-Enriched Pollen Grains of Olea europaea L.: Ca2+ Signaling and Germination Under Oxidative Stress
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2019.01611
Abstract: Selenium (Se) shows antioxidant properties that can be exploited in plants to combat abiotic stresses caused by reactive oxygen species produced in excess (ROS). Here, we show that the Se-fertilization of olive trees with sodium… read more here.
Keywords: ca2; selenium; pollen; ca2 homeostasis ... See more keywords
Mitochondrial Ca2+ Homeostasis: Emerging Roles and Clinical Significance in Cardiac Remodeling
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23063025
Abstract: Mitochondria are the sites of oxidative metabolism in eukaryotes where the metabolites of sugars, fats, and amino acids are oxidized to harvest energy. Notably, mitochondria store Ca2+ and work in synergy with organelles such as… read more here.
Keywords: cardiac remodeling; ca2 homeostasis; ca2; mitochondrial ca2 ... See more keywords