Dual Strategy of Ca2+ Influx and Collagen Denaturation to Remodel the Extracellular Matrix and Amplify Sonopiezoelectric Therapy
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Materials"
DOI: 10.1002/adma.202501642
Abstract: Extracellular matrix (ECM), a core member of tumor microenvironment, is ≈1.5‐fold harder than the surrounding normal tissues. Regulating the stiffness of ECM can significantly impact physiological activities of tumor cells, such as growth, differentiation, and… read more here.
Keywords: ca2 influx; therapy; collagen; extracellular matrix ... See more keywords
The steroid hormone 20-hydroxyecdysone upregulates calcium release-activated calcium channel modulator 1 expression to induce apoptosis in the midgut of Helicoverpa armigera.
Sign Up to like & getrecommendations! Published in 2017 at "Cell calcium"
DOI: 10.1016/j.ceca.2017.10.004
Abstract: Animal steroid hormones stimulate extracellular Ca2+ influx into cells; however, the mechanism remains unclear. In this study, we determined that the Ca2+ influx induced by steroid hormone 20-hydroxyecdysone (20E) is mediated by the calcium release-activated… read more here.
Keywords: steroid hormone; apoptosis; ca2 influx; calcium ... See more keywords
Malvidin-3-glucoside induces insulin secretion by activating the PLC/IP3 pathway and enhancing Ca2+ influx in INS-1 pancreatic β-cells
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-95808-y
Abstract: Malvidin-3-glucoside (M3G), an anthocyanin found in blueberries and grapes, shows promise as a natural anti-diabetic agent. However, its effect on insulin secretion and its underlying mechanisms remains unclear. This study investigated the impact of M3G… read more here.
Keywords: ca2 influx; malvidin glucoside; insulin secretion; secretion ... See more keywords
Ca2+ Influx Channel Inhibitor SARAF Protects Mice From Acute Pancreatitis.
Sign Up to like & getrecommendations! Published in 2019 at "Gastroenterology"
DOI: 10.1053/j.gastro.2019.08.042
Abstract: BACKGROUND & AIMS Pancreatitis is characterized by increased influx of Ca2+ into acinar cells, by unknown mechanisms. Inhibitors of Ca2+ influx channels could be effective in treating acute pancreatitis, but these have deleterious side effects… read more here.
Keywords: acute pancreatitis; pancreatitis; ca2 influx; acinar cells ... See more keywords
Oxoglaucine mediates Ca2+ influx and activates autophagy to alleviate osteoarthritis through the TRPV5/calmodulin/CAMK‐II pathway
Sign Up to like & getrecommendations! Published in 2021 at "British Journal of Pharmacology"
DOI: 10.1111/bph.15466
Abstract: Stimulation of calcium influx and suppression of autophagy play important roles in the pathogenesis of osteoarthritis (OA). In this study, we used a novel inhibitor of TRPV5 cation channels ‐ oxoglaucine to attenuate progression of… read more here.
Keywords: oxoglaucine mediates; osteoarthritis; mediates ca2; trpv5 ... See more keywords
Macrophages Modulated by Red/NIR Light: Phagocytosis, Cytokines, Mitochondrial Activity, Ca2+ Influx, Membrane Depolarization and Viability.
Sign Up to like & getrecommendations! Published in 2021 at "Photochemistry and photobiology"
DOI: 10.1111/php.13526
Abstract: Low-level light therapy (LLLT) is emerging as a promising therapeutic approach to modulate the biochemical and molecular processes within living cells. LLLT is known to produce local and systemic effects; therefore, immune cells in local… read more here.
Keywords: phagocytosis; light phagocytosis; influx membrane; ca2 influx ... See more keywords
Nitric oxide promotes GABA release by activating a voltage-independent Ca2+ influx pathway in retinal amacrine cells.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of neurophysiology"
DOI: 10.1152/jn.00803.2016
Abstract: Retinal amacrine cells express nitric oxide (NO) synthase and produce NO, making NO available to regulate the function of amacrine cells. Here we test the hypothesis that NO can alter the GABAergic synaptic output of… read more here.
Keywords: voltage; ca2; ca2 influx; retinal amacrine ... See more keywords
Transient Receptor Potential Channel, Vanilloid 5, Induces Chondrocyte Apoptosis in a Rat Osteoarthritis Model Through the Mediation of Ca2+ Influx
Sign Up to like & getrecommendations! Published in 2018 at "Cellular Physiology and Biochemistry"
DOI: 10.1159/000488725
Abstract: Background/Aims: Chondrocyte apoptosis is the most common pathological feature in cartilage in osteoarthritis (OA). Transient receptor potential channel vanilloid 5 (TRPV5) is important in regulating calcium ion (Ca2+) influx. Accumulating evidences suggest that Ca2+ is… read more here.
Keywords: chondrocyte apoptosis; trpv5; ca2; ca2 influx ... See more keywords
Increased Ca2+ influx through CaV1.2 drives aortic valve calcification
Sign Up to like & getrecommendations! Published in 2022 at "JCI Insight"
DOI: 10.1172/jci.insight.155569
Abstract: Calcific aortic valve disease (CAVD) is heritable, as revealed by recent GWAS. While polymorphisms linked to increased expression of CACNA1C — encoding the CaV1.2 L-type voltage-gated Ca2+ channel — and increased Ca2+ signaling are associated… read more here.
Keywords: cav1; increased ca2; ca2 influx; aortic valve ... See more keywords
Dystonia caused by ANO3 variants is due to attenuated Ca2+ influx by ORAI1
Sign Up to like & getrecommendations! Published in 2025 at "BMC Medicine"
DOI: 10.1186/s12916-024-03839-5
Abstract: Dystonia is a common neurological hyperkinetic movement disorder that can be caused by mutations in anoctamin 3 (ANO3, TMEM16C), a phospholipid scramblase and ion channel. We previously reported patients that were heterozygous for the ANO3… read more here.
Keywords: dystonia caused; ca2 influx; dystonia; ano3 variants ... See more keywords
Kynurenine-3-monooxygenase (KMO) broadly inhibits viral infections via triggering NMDAR/Ca2+ influx and CaMKII/ IRF3-mediated IFN-β production
Sign Up to like & getrecommendations! Published in 2022 at "PLoS Pathogens"
DOI: 10.1371/journal.ppat.1010366
Abstract: Tryptophan (Trp) metabolism through the kynurenine pathway (KP) is well known to play a critical function in cancer, autoimmune and neurodegenerative diseases. However, its role in host-pathogen interactions has not been characterized yet. Herein, we… read more here.
Keywords: ca2 influx; nmdar ca2; kynurenine monooxygenase; viral infections ... See more keywords