Trifluoperazine Elevates Intracellular Ca2+ Levels and Locks Open the Store‐Operated Calcium Entry Channels in Astrocytes
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DOI: 10.1002/glia.70052
Abstract: Trifluoperazine (TFP), a known inhibitor of Ca2+‐bound calmodulin (Ca2+/CaM), has been reported to elevate cytosolic Ca2+ levels by disinhibiting inositol 1,4,5‐triphosphate receptor 2 (IP3R2), thereby suppressing glioblastoma invasion and inducing apoptosis. Interestingly, TFP induces a… read more here.
Keywords: ca2 levels; store operated; ca2; sustained ca2 ... See more keywords
From Stores to Sinks: Structural Mechanisms of Cytosolic Calcium Regulation.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-319-55858-5_10
Abstract: All eukaryotic cells have adapted the use of the calcium ion (Ca2+) as a universal signaling element through the evolution of a toolkit of Ca2+ sensor, buffer and effector proteins. Among these toolkit components, integral… read more here.
Keywords: stores sinks; movement ca2; surface; ca2 ... See more keywords
Molecular Basis of S100A1 Activation and Target Regulation Within Physiological Cytosolic Ca2+ Levels
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DOI: 10.3389/fmolb.2020.00077
Abstract: The S100A1 protein regulates cardiomyocyte function through its binding of calcium (Ca2+) and target proteins, including titin, SERCA, and RyR. S100A1 presents two Ca2+ binding domains, a high-affinity canonical EF-hand (cEF) and a low-affinity pseudo… read more here.
Keywords: target; ca2 levels; s100a1; ca2 ... See more keywords
Expression of the Calcium-Binding Protein CALB1 Is Induced and Controls Intracellular Ca2+ Levels in Senescent Cells
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DOI: 10.3390/ijms23169376
Abstract: In response to many stresses, such as oncogene activation or DNA damage, cells can enter cellular senescence, a state of proliferation arrest accompanied by a senescence-associated secretory phenotype (SASP). Cellular senescence plays a key role… read more here.
Keywords: ca2 levels; senescence; intracellular ca2; cellular senescence ... See more keywords
TP53I11 Functions Downstream of Multiple MicroRNAs to Increase ER Calcium Levels and Inhibits Cancer Cell Proliferation
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DOI: 10.3390/ijms26010031
Abstract: Cells meticulously regulate free calcium ion (Ca2+) concentrations, with the endoplasmic reticulum (ER) being crucial for Ca2+ homeostasis. Disruptions in ER Ca2+ balance can contribute to various diseases, including cancer. Although considerable research has focused… read more here.
Keywords: ca2 levels; cancer; cell proliferation; calcium ... See more keywords