Usnea Acid-Incorporated Ca2+ /Mn2+ Ions Reservoirs for Elevated Ion-Interference Therapy through Synergetic Biocatalysis and Osmolarity Imbalance.
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DOI: 10.1002/smll.202300370
Abstract: Ion-interference therapy (IIT) utilizes ions to disturb intracellular biological processes and has been received increasing attention in tumor treatments recently. However, the low therapeutic efficiency still hinders its further biological applications. Herein, via a simple… read more here.
Keywords: ca2 mn2; interference therapy; ion interference; mn2 ions ... See more keywords
Golgi-localized calcium/manganese transporters FgGdt1 and FgPmr1 regulate fungal development and virulence by maintaining Ca2+ and Mn2+ homeostasis in Fusarium graminearum.
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DOI: 10.1111/1462-2920.16128
Abstract: Calcium and manganese transporters play important roles in regulating Ca2+ and Mn2+ homeostasis in cells, which is necessary for the normal physiological activities of eukaryotes. Gdt1 and Pmr1 function as calcium/manganese transporters in the Golgi… read more here.
Keywords: ca2 mn2; mn2 homeostasis; fggdt1 fgpmr1; golgi ... See more keywords
Cryo-EM structures of human SPCA1a reveal the mechanism of Ca2+/Mn2+ transport into the Golgi apparatus
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DOI: 10.1126/sciadv.add9742
Abstract: Secretory pathway Ca2+/Mn2+ ATPase 1 (SPCA1) actively transports cytosolic Ca2+ and Mn2+ into the Golgi lumen, playing a crucial role in cellular calcium and manganese homeostasis. Detrimental mutations of the ATP2C1 gene encoding SPCA1 cause… read more here.
Keywords: ca2 mn2; mn2 transport; structures human; human spca1a ... See more keywords